Dynamics of unstable chromosome aberrations in humans under anthropogenic exposure (literature review)



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Current paper is devoted to the review of literature sources that contain the data on the dynamics of unstable chromosome aberration in people affected by radiation and chemical exposure. It also deals with the frequency of unstable chromosome aberrations in unexposed individuals that compose the comparison group for the exposed people in various regions of the Russian Federation and some foreign countries. The studies reviewed cover a wide period of time, both short-and long-term effects of exposure, and include the analysis of different situations of radiation damage and chronic chemical exposure. The paper presents the comparative data on the frequency of unstable chromosome aberrations in the control groups and groups of exposed individuals that demonstrate different patterns of body response to external mutagens. The results of the studies emphasize that there is still the need to evaluate chromosome aberrations that develop in people under the effect of radiation and chemical factors. The importance of unified standards of unstable chromosome classification and measurement is also highlighted. It will improve the precision and comparability of the research findings.

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Yulia Rafisovna Akhmadullina

Southern Urals Federal Research and Clinical Center for Medical Biophysics of the Federal Medical Biological Agency

Email: akhmadullina.yul@yandex.ru
ORCID iD: 0000-0003-4394-2228
SPIN-code: 3511-3838

ведущий научный сотрудник лаборатории радиационной генетики

Russian Federation, 454141, г. Челябинск, ул.Воровского, 68‒А

Anastasia Veniaminovna Kupriyanova

ФГБУН Южно-Уральский научно-клинический центр медицинской биофизики ФМБА России

Author for correspondence.
Email: roksiika@mail.ru
ORCID iD: 0009-0005-8699-2745
Russian Federation, 454141, г. Челябинск, ул. Воровского, 68‒А

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