Genome and stress-reaction in animals and humans

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Abstract


Current data on the effects of stress at the level of the cell genomes of the central nervous system and peripheral organs in animals are discussed. Regulatory and structural genomic changes in the cells of the central nervous system under stress are considered as a mechanism for regulating the functions of the brain and peripheral organs that form the organism manifestations of stress. Based on the Yu.Ya. Kerkis and M.E. Lobashev point of view, we consider stress as a special physiological state of the nervous system, affecting the work and integrity of the genome in target cells in animals, and thus playing a major role in microevolutionary transformations.


Natalya A. Dyuzhikova

Author for correspondence.
dyuzhikova@mail.ru
SPIN-code: 6206-3889
Pavlov Institute of Physiology of the RAS
Russian Federation, Saint Petersburg

PhD, ScD, Head of the Lab of Genetics of Higher Nervous Activity

Eugene V. Daev

mouse_gene@mail.ru
Saint Petersburg State University
Russian Federation, Saint Petersburg

PhD, ScD, Professor, Department of Genetics and Biotechnology

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Supplementary files

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1. Fig. 1. Scheme of current view on stress development in animals taking into account systemic control of genetic processes at the cell genome level: PFC – prefrontal cortex; CRH – corticotropin-releasing hormone; GABA – γ-aminobutyric acid; GFs – growth factors; DA – dopamine; NE – norepinephrine; 5-HT – serotonin; NFkB – nuclear factor kappa-B; MAPK – mitogen-activated protein kinase; JAK/STAT – Janus Kinase/Signal Transducers and Activators of Transcription View (341KB) Indexing metadata

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