Vol 3, No 2 (2005)


pages 28-43 views

Increase of efficiency of QSAR — the analysis of carcinogenic activity of halogeneted hydrocarbons

Tarasov A.V., Abilev S.K., Velibekov R.M., Tarasov V.A.


The new principle of analysis of structureactivity of carcinogenic compounds is offered. It is basis on use a compound structural descriptors representing a combination untied among themselves of structural fragments of a molecule. The computer program is developed, allowing to generate every possible structural fragments of molecules of chemical compounds and their  combinations and to carry out selection of the compound descriptors statistically significantly influencing their biological activity. In work it is used the samples consisting of 89 halogeneted hydrocarbons for which their carcinogenic activity on rodents is investigated.
Ecological genetics. 2005;3(2):5-14
pages 5-14 views

Phylogenetic analysis of perfect repeats in the genomes of unicellular cyanobacteria

Mikheeva L.E., Orlov Y.L., Kolchanov N.A., Shestakov S.V.


We have fulfilled in silico research of number, structure, distribution and location of direct and inverted repeated sequences in eight complete genomes of unicellular cyanobacteria. Analysis of whole genome repeats has shown utility of this approach for purposes of molecular phylogeny and ecological genomics. Comparative analysis of nonrandom repeats patterns has allowed: 1) to confirm the close genetic relationship of two Prochlorococcus marinus strains (MED4 and SS120) that have reduced genomes and inhabit the econiches with different light intensities; 2) to suggest the close phylogenetic relationship of genomes Prochlorococcus marinus MIT9313 and Synechococcus WH8102 that significantly differ by sets of lightharvesting photosystem; 3) to  reveal specific differences in genome organization between marine and freshwater cyanobacteria.
Ecological genetics. 2005;3(2):15-21
pages 15-21 views


Larionova A.Y., Ekart A.K.


On the basis of analysis for 19 genes coding allozyme diversity of 11 enzymes (IDH, NDH, MDH, SKDH, FE, GDH, PGM, SOD, GOT, LAP, PGI) the data about genetic diversity, structure and degree of differentiation of Siberian fir populations (Abies sibirica Ledeb) located at varied elevations in Western Sayan (400 m, 1000 m and 1500 m) were obtained. It was established that the most significant differences at genetic structure are observed between distant from each other along an elevation gradient low mountain and high mountain populations.
Ecological genetics. 2005;3(2):22-27
pages 22-27 views

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