Vol 9, No 3 (2011)


Gene polymorphism, ecogenetic diseases and predictive personalized medicine

Baranov V.S.


The problems concerned with identification of genes involved in the origin of complex diseases, analysis of their epistatic (gene to gene) interactions and adequate interpretation of genetic testing results in Predictive Personalized Medicine (PPM) are reviewed. The practical meaning of already available PPM data, the options and volume of their feasible clinical implications are discussed. 
Ecological genetics. 2011;9(3):3-14
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Lebedev I.N.


Early stages of human embryo development are characterized by an extremely high incidence of reproductive losses. Genomic mutations are the main contributing factor in this phenomenon. However, a significant part of miscarriages cannot explained by current genetic or cytogenetic concepts. A possible impact of abnormalities of the epigenetic genome organization into etiology of reproductive wastages is discussed in the current review. Characteristics of aberrant epigenetic modifications, ontogenetic and molecular mechanisms of their appearance are given in the light of genomic imprinting. 
Ecological genetics. 2011;9(3):15-19
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Methylation anomalies in cancerogenesis: search for new genes, development of methods and DNA-markers for diagnosis

Zaletaev D.V., Strelnikov V.V., Kekeeva T.V., Zemliakova V.V., Kuznetsova E.B., Mikhaylenko D.S.


The report considers the epigenetic defects and their diagnostics in tumors. Aberrant methylation of the promoter or regulatory region of a gene results in its functional inactivation, which is phenotypically similar to structural deletion. Cancerogenesis-associated genes are often methylated in tumors. Tumors differ in methylation frequencies, allowing differential diagnostics. Aberrant methylation of tumor suppressor genes occurs in early cancerogenesis, and its detection may be employed in presymptomatic and noninvasive diagnostics of tumors. 
Ecological genetics. 2011;9(3):27-32
pages 27-32 views

Geograpahic distribution of allele frequencies of alcohol metabolism genes and possible determinants of inter population diversity in human

Borinskaya S.A., - -., Kalina N.R., Shirmanov V.I., Koshechkin V.A., Yankovsky N.K.


ADH1B and ALDH2 genes are coding for key alcohol metabolism enzymes. Both allele ADH1B*Arg48His and ALDH2*504Lys are associated with lower alcohol consumption level. The allele frequencies were determined for rather few populations of Russia. The article presents аn updated review on the allele frequencies worldwide including the data for populations of Russia which were determined by our lab in recent years. Possible role of factors influencing the peculiarities of ADH1B*48His and ALDH2*504Lys allele frequencies geographic distribution are being discussed. 
Ecological genetics. 2011;9(3):47-56
pages 47-56 views

Analysis of congenital morphogenetic variants in children of Chechen Republic living in the regions with high level petrolium in soil

Djambetova P.M., Molochaeva L.G., Mahtieva A.B., Sycheva L.P.


 For the first time an analysis of congenital morphogenetic variants (CMV) in children living in conditions of pollution products of primary processing of oil is carried out and clear evidence unfavorable effect of exposure to high levels of petroleum in soil on the health of children are received. The average number of CMV for 1 child in a conventionally clean area — s. Goyty was 2,20 ± 0,18, and in areas with petroleum in  soil s. Dolinsk and Mesker-Yurt, 3,15 ± 0,21 and 2,79 ± 0,19, respectively. 
Ecological genetics. 2011;9(3):89-94
pages 89-94 views

Evolution of micro-symbionts of cultured plants: experimental and mathematical models

Provorov N.A., Vorobyov N.I.


Formation of the cultured flora resulted in a decrease of plant symbiotic potential based on interactions with beneficial microorganisms. This decrease leads to transformation of plant micro-symbionts into the non-adaptive forms caused by: а) blocking the selection in favor of mutualistic strains; б) horizontal gene transfer in the microbial communities resulted in formation of virulent “symbiotic cheaters”. Mathematical simulation suggests that these tendencies may be overcome by formation of the optimal population structures in symbiotic system which should possess a high integrity and specificity of partners’ interactions as well as by a tolerance to the invasions of non-active aboriginal strains from the local soil populations. 
Ecological genetics. 2011;9(3):20-22
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Is biological invasion crucible for evolution?

Orlova M.I.


During the invasion process multiply introductions via invasion corridors support contacts of propagules from populations isolated before. The contacts occur outside their native range in conditions of differently disturbed ecosystems. Universal genetic mechanisms form the material that is both diverse and unique for natural selective pressure in these contact zones. Invasions provide prerequisites for co-evolution of species having the same origin (and so far period of preceding co-evolution) and those of different regions. Their further co-evolution can occur in recipient system including as formation of new assemblages. 
Ecological genetics. 2011;9(3):33-46
pages 33-46 views


Tokmakov S.V., Mukhina Z.M., Bogomaz D.I., Matveeva T.V.


Red rice is the worst field weed in all rice-cultivation areas. Early diagnosis of red rice in primary seed breeding program is an overriding task, which solution directly influences the quality of the rice seeds. Red and red-brown colors of pericarp are determined by two loci at least: Rc and Rd, expressing in conjunction with the Rc gene. In this study we have developed an intragenic codominant molecular marker for the Rc gene and tested it with contrasting as to the seed colour rice varieties examined feature. The efficacy of the marker has been shown for 1142 families of rice, each sample containing 120 plants. 
Ecological genetics. 2011;9(3):57-67
pages 57-67 views


Gorbunov A.B., Padutov V.E., Baranov O.U.


Interspecies hybrids Ribes atropurpureum × Ribes hispidulum occurring on the Salair ridge were revealed and studied on the basis of assessment of their morphological traits and molecular and genetic analysis. 
Ecological genetics. 2011;9(3):68-74
pages 68-74 views

The molecular basis for construction of highly productive ecologically sustainable agrocenoses

Tikhonovich I.A., Provorov N.A.


The methodology is suggested for analyzing the variability and heredity in super-organism genetic systems of different complexity ranging from two-component plant-microbe and animal-microbe symbiosis to the endosymbiotic and soil microbial communities. The approaches based on symbiogenetics and metagenomics may be used for development of highlyproductive ecologically sustainable agrocenoses based on the substitution of agrochemicals (mineral fertilizers, pesticides) by the microbial preparations. A possibility is emphasized to use the natural analogs of agrocenoses for development of models to implement the directed construction and improvement of productivity in the sustainable agricultural systems. 
Ecological genetics. 2011;9(3):23-26
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Anti-mutagenic action of synthetic “epitalon” peptide in mice with different body colour

Mylnikov S.V., Pavlova N.V., Barabanova L.V.


Epitalon demonstrate differences in antimutagenic activity after cyclophosphamide injection in mice. We demonstarted protection effects in white mice, but not in grey ones. Those effects may be explained by different neuro-humoral status and stress-resistance of the animals. 
Ecological genetics. 2011;9(3):75-88
pages 75-88 views

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