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The frequency of chromosomal aberrations in individuals chronically in contact with excess dosages of fluorides
- Authors: Volobaev V.P.1, Lytkina E.S.2, Schetnikova E.A.1, Vdovina E.D.1, Mikheeva E.E.3, Gurevich E.B.4, Mishchenko E.P.5, Larionov A.V.1
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Affiliations:
- Kemerovo State University
- National Research Tomsk State University
- Municipal Budgetary Educational Institution Lyceum No. 62
- Novokuznetsk city clinical hospital №1
- Novokuznetsk City Clinical Hospital №22
- Issue: Vol 19, No 1 (2021)
- Pages: 59-66
- Section: Human ecological genetics
- URL: https://journals.eco-vector.com/ecolgenet/article/view/20645
- DOI: https://doi.org/10.17816/ecogen20645
- ID: 20645
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Abstract
BACKGROUND: Chronic excess human exposure to fluorides is an underestimated problem. There is information that fluorides are capable of exerting a genotoxic effect in vitro and in vivo. The data obtained on human populations are limited and contradictory. More research is needed.
MATERIALS AND METHODS: The material for the study was peripheral venous blood taken from residents of the city of Novokuznetsk. The material was selected in four groups: workers of the Novokuznetsk Aluminum Plant (NkAZ) with fluorosis, NkAZ workers without pathology, residents of the area adjacent to NkAZ, residents of the city living away from the industrial zone. The frequency of chromosomal abnormalities in blood leukocytes was estimated using the method of accounting for metaphase chromosomal aberrations, as well as the concentration of fluoride ion in blood plasma by direct potentiometry.
RESULTS: A significant increase in the frequency of aberrant metaphases in blood leukocytes was observed among workers at an aluminum smelter compared to control, workers with fluorosis compared to workers without pathology, and residents of the area adjacent to the plant compared to residents of the city living far from the industrial zone. A correlation of the frequency of chromosomal aberrations with the concentration of fluoride ion in blood plasma was noted.
CONCLUSION: The results obtained confirm the ability of the industrial factor of the aluminum smelter to exert a genotoxic load on the human population. The presence of an association of fluoride factor with chromosomal abnormalities in blood leukocytes is likely.
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About the authors
Valentin P. Volobaev
Kemerovo State University
Author for correspondence.
Email: volobaev.vp@gmail.com
ORCID iD: 0000-0001-7355-9882
SPIN-code: 2805-5700
Junior Researcher
Russian Federation, 6 Krasnaya str., Kemerovo, 650000Ekaterina S. Lytkina
National Research Tomsk State University
Email: katya.serdyukova.1997@mail.ru
Master degree
Russian Federation, TomskEkaterina A. Schetnikova
Kemerovo State University
Email: schetnikovakat@gmail.com
Student
Russian Federation, 6 Krasnaya str., Kemerovo, 650000Evgenia D. Vdovina
Kemerovo State University
Email: vdovina_ed@gkl-kemerovo.ru
Student
Russian Federation, 6 Krasnaya str., Kemerovo, 650000Ekaterina E. Mikheeva
Municipal Budgetary Educational Institution Lyceum No. 62
Email: Ekaterina.Eduardovna@yandex.ru
Teacher
Russian Federation, KemerovoElena B. Gurevich
Novokuznetsk city clinical hospital №1
Email: elenagurevich1968@gmail.com
Head of the Center for Professional Pathology
Russian Federation, NovokuznetskElena P. Mishchenko
Novokuznetsk City Clinical Hospital №22
Email: pol2@kb22.ru
Deputy Chief Physician
Russian Federation, NovokuznetskAlexey V. Larionov
Kemerovo State University
Email: alekseylarionov09@gmail.com
PhD, Cand. Ci. (Med.), Associate Professor, Department of Genetics
Russian Federation, 6 Krasnaya str., Kemerovo, 650000References
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