The frequency of chromosomal aberrations in persons chronically in contact with the factor of industrial exposure of the aluminum plant

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Abstract


Background: Chronic excess human exposure to fluorides is an underestimated problem. There is information that fluorides are capable of exerting a genotoxic effect in vitro and in vivo. The data obtained on human populations are limited and contradictory. More research is needed.

Materials and methods: The material for the study was peripheral venous blood taken from residents of the city of Novokuznetsk. The material was selected in four groups: workers of the Novokuznetsk Aluminum Plant (NkAZ) with fluorosis, NkAZ workers without pathology, residents of the area adjacent to NkAZ, residents of the city living away from the industrial zone. The frequency of chromosomal abnormalities in blood leukocytes was estimated using the method of accounting for metaphase chromosomal aberrations, as well as the concentration of fluoride ion in blood plasma by direct potentiometry.

Results: A significant increase in the frequency of aberrant metaphases in blood leukocytes was observed among workers at an aluminum smelter compared to control, workers with fluorosis compared to workers without pathology, and residents of the area adjacent to the plant compared to residents of the city living far from the industrial zone. A correlation of the frequency of chromosomal aberrations with the concentration of fluoride ion in blood plasma was noted.

Conclusion: The results obtained confirm the ability of the industrial factor of the aluminum smelter to exert a genotoxic load on the human population. The presence of an association of fluoride factor with chromosomal abnormalities in blood leukocytes is likely.


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About the authors

Valentin P. Volobaev

Kemerovo State University

Author for correspondence.
Email: volobaev.vp@gmail.com
ORCID iD: 0000-0001-7355-9882
SPIN-code: 2805-5700

Russian Federation, 6 Krasnaya str., Kemerovo, 650000

Junior Researcher

Ekaterina S. Lytkina

National Research Tomsk State University

Email: katya.serdyukova.1997@mail.ru

Russian Federation, Tomsk

Master degree

Ekaterina A. Schetnikova

Kemerovo State University

Email: schetnikovakat@gmail.com

Russian Federation, 6 Krasnaya str., Kemerovo, 650000

Student

Evgenia D. Vdovina

Kemerovo State University

Email: vdovina_ed@gkl-kemerovo.ru

Russian Federation, 6 Krasnaya str., Kemerovo, 650000

Student

Ekaterina E. Mikheeva

Municipal Budgetary Educational Institution Lyceum No. 62

Email: Ekaterina.Eduardovna@yandex.ru

Russian Federation, Kemerovo

Teacher

Elena B. Gurevich

Novokuznetsk city clinical hospital №1

Email: elenagurevich1968@gmail.com

Russian Federation, Novokuznetsk

Head of the Center for Professional Pathology

Elena P. Mishchenko

Novokuznetsk City Clinical Hospital №22

Email: pol2@kb22.ru

Russian Federation, Novokuznetsk

Deputy Chief Physician

Alexey V. Larionov

Kemerovo State University

Email: alekseylarionov09@gmail.com

Russian Federation, 6 Krasnaya str., Kemerovo, 650000

PhD, Cand. Ci. (Med.), Associate Professor, Department of Genetics

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Copyright (c) 2021 Volobaev V., Ekaterina S., Shchetninikova E., Korotkova A., Vdovina E.D., Mikheeva E.E., Gurevich E.B., Mishchenko E.P., Larionov A.V.



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