Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people



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Abstract

We analyzed AGT (M235T), ACE (I/D), AGTR1 (A1166C) genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people by PCR/RFLP methods. It was shown increasing of M/T genotype of AGT gene in rowers compared with population group (46 and 34%, accordantly), I/D of ACE (55 and 48%, accordantly) and decreasing of A/C genotype of AGTR1 gene (38 and 51%). It was detected significantly increasing of M/T genotype of AGT gene elderly people compared with population group (56 and 34%, accordantly, x2=l 1,828, p=0,0006). The received data allow to make the assumption of a possible role renin-angiotensine systems in process of ageing and active physical working capacitу

About the authors

Andrey S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: anglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3, Russia

Oleg S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: olglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3. Russia

Mikhail V Moskalenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: mvmos@mail.ru

Viktor A Rogozkin

P. F. Lesgaft National State University of Physical Education, Sport and Health, Saint-Petersburg, RF

Email: rogozkin@mail.ru

Tatyana E Ivashchenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: iagmail@ott.ru Mendeleyev Line, 3, Saint-Petersburg, 199034, Russia

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

References

  1. Баранов B.C., Баранова Е.В., Иващенко Т.Э., Асеев М.В. Геном человека и гены «предрасположенности» (Введение в предиктивную медицину) -СПб.: Интермедика, 2000 г.
  2. Баранов B.C. Молекулярная медицина: молекулярная диагностика, превентивная медицина и генная терапия//Молекулярная биология. -2000. -Т. 34, № 4. -С. 684-695.
  3. Определение генетической предрасположенности к наследственным и мультифакториальным заболеваниям. Генетический паспорт: Методические рекомендации. -СПб.: Фолиант, 2001. -48 с.
  4. Рогожин В.А. Расшифровка генома человека и спорт//Теория и практика физической культуры. -2001. -№. 6. -С. 60-63.
  5. Степанов В.А. Этногеномика неселения Северной Евразии. -Томск: Печатная мануфактура, 2002. -244 с.
  6. Karjalainen J., Kujala U.M., Stolt A., Mantysaari M., Viitasalo M., Kainulainen K., Kontula K. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes//J. Am. Coll. Cardiol. -1999. -Vol. 34. -P. 494-499.
  7. Nazarov L.B., Woods D.R., Montgomery H.E., Shneider O.V., Kazakov V.I., Tomilin N.V., Rogozkin V.A. The angiotensin converting enzyme I/D polymorphism in Russian athletes//Eur. J. Hum. Genet. -2001. -Vol. 9. -P. 797-801.
  8. Montgomery H.E., Marshall R., Hemingway H., et al. Human gene for physical performance//Nature.-1998. -Vol. 21. -P. 221-222.

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Copyright (c) 2004 Glotov A.S., Glotov O.S., Moskalenko M.V., Rogozkin V.A., Ivashchenko T.E., Baranov V.S.

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