Analysis of genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people

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Abstract


We analyzed AGT (M235T), ACE (I/D), AGTR1 (A1166C) genes polymorphisms of renin-angiotensine systems in population, athletes and elderly people by PCR/RFLP methods. It was shown increasing of M/T genotype of AGT gene in rowers compared with population group (46 and 34%, accordantly), I/D of ACE (55 and 48%, accordantly) and decreasing of A/C genotype of AGTR1 gene (38 and 51%). It was detected significantly increasing of M/T genotype of AGT gene elderly people compared with population group (56 and 34%, accordantly, x2=l 1,828, p=0,0006). The received data allow to make the assumption of a possible role renin-angiotensine systems in process of ageing and active physical working capacitу

About the authors

Andrey S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: anglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3, Russia

Oleg S Glotov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: olglotov@mail.ru 199034, Saint-Petersburg, Mendeleyevskaya line, 3. Russia

Mikhail V Moskalenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: mvmos@mail.ru

Viktor A Rogozkin

P. F. Lesgaft National State University of Physical Education, Sport and Health, Saint-Petersburg, RF

Email: rogozkin@mail.ru

Tatyana E Ivashchenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: iagmail@ott.ru Mendeleyev Line, 3, Saint-Petersburg, 199034, Russia

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

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Copyright (c) 2004 Glotov A.S., Glotov O.S., Moskalenko M.V., Rogozkin V.A., Ivashchenko T.E., Baranov V.S.

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