Effective of antiviral therapy of HIV infection and intercurrent diseases in children

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The study included 366 HIV-infected children (under-23) and 350 children with perinatal contact with HIV infection (R-75), consisting on the dispensary account in the Department of motherhood and childhood of the Saint Petersburg city AIDS center. The vast majority of children with perinatal HIV receive HAART (95.0%) with high efficacy (undetectable viral load, normalization of CD4 lymphocytes, the absence of clinical manifestations). In the structure of opportunistic viral infections (herpes, respiratory infections) 40.0%, bacterial (bronchitis, tonsillitis, pyoderma, pulmonary tuberculosis) - 28.6%, fungal infections (candidiasis mucous membranes of the oral cavity) and Pneumocystis pneumonia - 31.4%. Complex therapy (etiotropic, pathogenetic, symptomatic) acute respiratory viral infections in children with B-23 and R-75, allows us to achieve in the early stages (6 days treatment) of the regression of the main symptoms of acute respiratory diseases.

Vladimir N Timchenko

Author for correspondence.
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Dr Med Sci, Professor, Head, Department of Infectious Diseases in Children in the name of M. G. Danilevich

Elena B Yastrebova

I.P. Pavlov First St Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Dr Med Sci, Associate Professor.

Oksana V Bulina

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Associate Professor.

  • Национальные клинические рекомендации по диагностике и лечению ВИЧ-инфекции у детей и подростков / Национальная ассоциация вирусологов. — М., 2013. — 16 с. [National clinical guidelines for the diagnosis and treatment of HIV infection in children and adolescents. National Association of Virology. Moscow; 2013. P. 16. (In Russ.)]
  • Тимченко В.Н., Архипова Ю.А., Булина О.В. Опыт лечения хронического вирусного гепатита С у детей, рожденных ВИЧ-позитивными женщинами // Детские инфекции. — 2015. — Т. 14. — № 4. — С. 45–49. [Timchenko VN, Arkhipov AYu, Bulina OV. Experience in the treatment of chronic viral hepatitis C in children born to HIV-positive women. Children’s infections. 2015;14(4):45-49. (In Russ.)]
  • Тимченко В.Н., Архипова Ю.А., Джангавидзе Н.Д. Клинико-эпидемиологические особенности ВИЧ-инфекции у детей первого года жизни // ВИЧ-инфекция и иммуносупрессии. — 2012. — Т. 4. — № 4. — С. 80–87. [Timchenko VN, Arkhipova YuA, Dgangavadze ND. The clinical-epidemiological features of HIV-infectionfor the children of first-year of life. HIV-infection and Immunosuppressions. 2012;4(4):80-87. (In Russ.)]
  • Тимченко В.Н., Архипова Ю.А., и др. Особенности физического развития детей первого года жизни, рожденных ВИЧ-позитивными женщинами // Педиатр. — 2010. — Т. 1. — № 2. — С. 97–101. [Timchenko VN, Arkhipova YuA. The features of physical development of first-year infants born to HIV-positive women. Pediatr. 2010;1(2):97-101. (In Russ.)]
  • Ястребова Е.Б., Рахманова А.Г., Курильская М.Б., и др. Перинатальная ВИЧ-инфекция у детей Санкт-Петербурга (клиника, диагностика, лечение) // Эпидемиология и инфекционные болезни. — 2006. — № 6. — С. 27–31. [Yastrebova EB, Rakhmanova AG, Kurilskaya MB, et al. Perinatal HIV-infection for the children of Saint Petersburg (clinic, diagnostics, treatment). Epidemiology and Infectious Diseases. 2006;(6):27-31. (In Russ.)]
  • Ястребова Е.Б., Рахманова А.Г., Щербук Ю.А. Пути передачи ВИЧ как факторы риска прогрессирования заболевания у детей // Детские инфекции. — 2011. — Т. 10. — № 4. — С. 14–17. [Yastrebova EB, Rakhmanova AG, Shcherbuk YuA. Ways of transmission of HIV as risk of progress of disease factors for children. Detskie infekcii. 2011;10(4)14-17. (In Russ.)]
  • Ястребова Е.Б., Самарина А.В. Анализ клинико-эпидемиологических характеристик ВИЧ-инфицированных детей в Санкт-Петербурге // ВИЧ-инфекция и иммуносупрессии. — 2014. — Т. 6. — № 2. — С. 74–79. [Yastrebova EB, Samarina AV. Analysis of clinical-epidemiological descriptions of the HIV-infected children in Saint Petersburg. HIV-infection and Immunosupressions. 2014;6(2)74-79. (In Russ.)]


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