Diagnostic symptoms of endotoxicosis during pregnancy as a prognostic of sepsis

Abstract

Objective: The work was aimed at the elaboration of the diagnostic criteria of endotoxicosis during pregnancy, previous to the development of postnatal sepsis.

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Methods: General clinical examination, ultrasound investigation, dopplerometry, bactériologie, immunologic and haemostasiologic examination.

Results: The diagnostic criteria of the developing endotoxicosis are the combination of the following symptoms:

Presence of the one or more inflammatory nidi, even at the stage of remission.

A high degree of vaginal bacterization or bacteriuria.

Appearance and increase of proteins of acute phase of inflammation and placental macroglobulin over 30 ng/ml.

Anemia, hypoproteinemia, lymphopenia, leukocytosis with a shift to the left.

Deviation in hemostasiograms.

Reduction of general and local hemodynamic reserves.

Indications оf fetal infection.

Increase of middle molecules.

Signs of atypical and constant threat of abortion.

Conclusions: Effectlessness of the complex of efferent detoxicational measures indicates the necessity of pregnancy termination. Prolongation of pregnancy without detoxication or the effect results in serious septic complications in 75-80%.