Melatonin in the pathogenesis of preeclampsia

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Abstract

The review presents the results of experimental studies that have revealed the molecular mechanisms underlying implantation and placentation controlled by cytokines, chemokines, adhesion molecules, hormones, as well as transcription and growth factors, and have indicated the key regulatory and protective role of melatonin. It has been shown that low production of the hormone and lack of its circadian rhythm underlie the disruption of endogenous antioxidant protection and contribute to oxidative stress leading to the development of preeclampsia. The necessity of using melatonin as a neuroimmunoendocrine marker of pathology is emphasized in this review article, which will allow for developing new approaches to its use for the prevention and treatment of preeclampsia, as well as its adverse consequences, such as obesity, type 2 diabetes mellitus, renal failure, and cardiovascular pathology.

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About the authors

Inna I. Evsyukova

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: eevs@yandex.ru
ORCID iD: 0000-0003-4456-2198
SPIN-code: 4444-4567
Scopus Author ID: 520074

MD, Dr. Sci. (Med.), Professor

Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034

Igor M. Kvetnoy

Saint-Petersburg State Research Institute of Phthisiopulmonology; Saint-Petersburg State University

Author for correspondence.
Email: igor.kvetnoy@yandex.ru
ORCID iD: 0000-0001-7302-5581
ResearcherId: H-4882-2016

MD, PhD, DSci (Medicine),

Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; Saint Petersburg

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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