Email this article Immune interface of patients with reproductive loss in the North-West region of the Russian Federation
- Authors: Shengeliia M.O.1, Bespalova O.N.1, Zhernakova T.S.1, Zagaynova V.A.1, Agnayeva A.O.2, Pachuliia O.V.1, Chepanov S.V.1, Domanskaya M.A.3, Selkov S.A.1, Kogan I.Y.1
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Affiliations:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Saint-Petersburg State Pediatric Medical University
- Academician I.P. Pavlov First St. Petersburg State Medical University
- Issue: Vol 71, No 5 (2022)
- Pages: 51-63
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/110886
- DOI: https://doi.org/10.17816/JOWD110886
- ID: 110886
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Abstract
BACKGROUND: Currently, more than a hundred immunological biomarkers are known that are important for fertilization, implantation and placentation.
AIM: The aim of this study was to assess the immunological profile for the main allo- and autoantibodies in women with reproductive loss and infertility in the North-West region of the Russian Federation.
MATERIALS AND METHODS: This prospective cohort study was conducted at the stage of pregnancy planning in 325 women with reproductive disorders (spontaneous miscarriages, missed abortions, infertility, IVF failures) on the premises of the D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine (St. Petersburg, Russia) from 2015 to 2022. The study assessed the immune interface of women with a history of reproductive disorders and matching loci of the HLA class II system (DQA1, DQB1, DRB1) among 100 married couples.
RESULTS: In couples with reproductive disorders, coincidences of HLA class II allele (DQA1, DQB1, DRB1) loci were diagnosed in 14% (at 2 loci), 31% (at 3 loci), 14% (at 4 loci), 3% (at 5 loci) and 10% (at 6 loci) of couples. In 34.4% of women, we found an elevated number of spontaneously activated NK cells (CD107a). As many as 31.15% of women had a high level of antibodies to human chorionic gonadotropin. We found that 22.34% of women were carriers of at least one criteria antiphospholipid antibody, and 3.16% of women of two antiphospholipid antibodies. The diagnosis of antiphospholipid syndrome was not established in any patient. Non-criteria antiphospholipid antibodies were found in 6.15% of women. In 12.2% of women, we diagnosed a high level of antibodies to thyroperoxidase, while the average antibody value was 30.76 IU/ml. Only one patient had a high level of antisperm antibodies in the blood serum.
CONCLUSIONS: In 59% of patients with a history of reproductive disorders, we identified some features of the immunological profile, which can lead to this pathology. Thus, 32% of women had a deviation in one immunological parameter, while 20% of patients had it in two parameters, and 7% in three or more parameters.
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About the authors
Margarita O. Shengeliia
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: bakleicheva@gmail.com
ORCID iD: 0000-0002-0103-8583
Scopus Author ID: 57203248029
Russian Federation, Saint Petersburg
Olesya N. Bespalova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: shiggerra@mail.ru
ORCID iD: 0000-0002-6542-5953
SPIN-code: 4732-8089
ResearcherId: D-3880-2018
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgTatyana S. Zhernakova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: tatazhernakova@gmail.com
ORCID iD: 0000-0002-5131-4363
Russian Federation, Saint Petersburg
Valeria A. Zagaynova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: zagaynovav.al.52@mail.ru
ORCID iD: 0000-0001-6971-7024
Scopus Author ID: 57222615411
Russian Federation, Saint Petersburg
Alana O. Agnayeva
Saint-Petersburg State Pediatric Medical University
Email: forlucky999@mail.ru
ORCID iD: 0000-0001-8978-3221
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgOlga V. Pachuliia
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: for.olga.kosyakova@gmail.com
ORCID iD: 0000-0003-4116-0222
Scopus Author ID: 57299197900
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgSergey V. Chepanov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: chepanovsv@gmail.com
ORCID iD: 0000-0001-6087-7152
Scopus Author ID: 56399329700
ResearcherId: M-3471-2015
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgMaria A. Domanskaya
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: mdomanskaya@yandex.ru
Russian Federation, Saint Petersburg
Sergey A. Selkov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: selkovsa@mail.ru
ORCID iD: 0000-0003-1560-7529
Scopus Author ID: 6507854443
ResearcherId: G-2059-2014
MD, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation
Russian Federation, Saint PetersburgIgor Yu. Kogan
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
SPIN-code: 6572-6450
Scopus Author ID: 56895765600
ResearcherId: P-4357-2017
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, Saint PetersburgReferences
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