Determination of pH as a method of prevention of preterm birth of infectious genesis in women with a history of miscarrage

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There is substantial evidence that urogenital infection is one of the major causes of preterm birth, with bacterial vaginosis being one of these infections. Timely diagnosis and treatment of this condition significantly reduce the rate of preterm birth. The aim of this study was to evaluate the method of pH determination of vaginal fluid in women at a risk of preterm birth. A total of 66 women were included in the study. The women were divided into two groups. Group 1 consisted of 30 women, who measured vaginal pH from week 12 and 36 of gestation twice a week using the test рН-Balance (PremiumDiagnostics, Germany). Group 2 comprised 36 women, who did not measure vaginal pH (control group). Abnormal рН (>4,4) were observed in 9 women (30.0 %). Of them, in 8 women a urogenital infection was observed. All patients received etiotropic treatment. pH measuring in women with a history of miscarriage resulted in 4.5-fold reduction of preterm birth (from 30.0 to 6.7 %). In the control group the was no significant reduction in the rate of preterm birth (from 22.2 to 19.4 %).

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About the authors

Tamara Aleksandrovna Pluzhnikova

maternity hospital N 1

Cand. of Medical science, chief of Center of prophylaxis and treatment of miscarriage


  1. Демидова Е. М. Патогенез привычного выкидыша. Автореф. дис… д-ра мед. наук. М.; 1993.
  2. Доброхотова Ю. Э., Джобава Э. М., Мандрыкина Ж. А., Данелян С. Ж., Судакова Г. Ю. Угроза прерывания беременности различных сроков гестации. Тактика и стратегия современной терапии. М.; 2013.
  3. Земляная А. А. Профилактика преждевременного прерывания беременности у женщин с привычным невынашиванием и высоким риском развития воспалительных осложнений. Автореф. дис… канд. мед. наук. М.; 1993.
  4. Радзинский В.Е, Хамошина М. Б., Календжян А. С., Чатчаева А. И., Архипова М. П. Эффективная коррекция нарушений биоценоза влагалища вне- и во время беременности: почему это важно и что нового? Доктор Ру. 2011; 9 (68): 26-32.
  5. Сидельникова В. М., Сухих Г. Т. Невынашивание беременности. М.; 2010.
  6. Хамошина М. Б., Радзинский В.Е, Календжян А. С., Рубцова А. Ю. Нарушения микробиоценоза урогенитального тракта: грани проблемы, перспективы коррекции и профилактики. Вопросы гинекологии, акушерства и перинатологии. 2009; 8 (5): 69-74.
  7. Хойме У. Б., Грош А., Румер Ф. М., Залинг Э. Бактериальный вагиноз как фактор риска. Результаты эрфуртской программы по предотвращению преждевременных родов. Гинекология. 2000; 33: 331-5.
  8. Хойме У. Б., Мёллер У., Залинг Э. Результаты и возможные последствия Тюрингской программы по предотвращению преждевременных родов 2000 года. Родовспоможение и гинекология. 2002; 52: 257-63.
  9. Campos A. A. S. et al. Comparative study between the pH test and of the KOH versus Nugent score for diagnosis of bacterial vaginosis in pregnant women. Rev. Bras. Gynecol. Obstet. 2012; 34 (5): 209-14.
  10. Dadhwal V., Hariprasad R., Mitta S., Kapi A. Prevalence of bacterial vaginosis in pregnant women and predictive value of clinical diagnosis. Arch. Gynecol. Obstet. 2010; 281: 101-4.
  11. Leitich H. et al. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am. J. Obstet. Gynecol. 2003; 189 (1): 139-47.
  12. Mittal V., Jain A., Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries. J. Infect. Dev. Ctries. 2012; 6 (5): 373-7.
  13. Saling E., Schreiber M., al-Taie T. A simple, efficient and inexpensive program for preventing prematurity. J. Perinat. Med. 2001; 29 (3): 199-211.



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