Email this article Clinical and immunological criteria for the use of intravenous immunoglobulins in women with reproductive failures
- Authors: Agnaeva A.O.1, Bespalova O.N.1, Sokolov D.I.1, Mikhailova V.A.1, Chepanov S.V.1, Selkov S.A.1, Kogan I.Y.1
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Affiliations:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Issue: Vol 72, No 4 (2023)
- Pages: 37-46
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/202790
- DOI: https://doi.org/10.17816/JOWD202790
- ID: 202790
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Abstract
BACKGROUND: In obstetrics and reproductive medicine, the use of intravenous immunoglobulin remains controversial. There are no clearly developed indications for immunoglobulins therapy. The search for immunological criteria for prescribing this therapy is an urgent task
AIM: The aim of this study was to evaluate the effectiveness of the use of intravenous immunoglobulins in the complex therapy of women with multiple reproductive losses associated with changes in the quantitative and functional parameters of natural killer cells.
MATERIALS AND METHODS: Group 1 consisted of 61 women with recurrent miscarriage; group 2 involved 40 women with two or more in vitro fertilization failures, while group 3 comprised 27 healthy fertile individuals. The activity of blood natural killer cells was assessed by CD107a expression before and after activation. Patients with altered natural killer cell activity received intravenous immunoglobulins therapy under the control of the dynamics of immunological parameters.
RESULTS: The number of natural killer cells that expressed CD107a before and after activation differed between the study groups. In patients receiving intravenous immunoglobulins, gestational complications were observed less frequently, with the incidence of biochemical pregnancy being higher.
CONCLUSIONS: In patients with early reproductive failures (such as recurrent miscarriage and in vitro fertilization failures) and immunological abnormalities in the form of altered Natural killer cell activity, the use of intravenous immunoglobulins has an immunomodulatory and clinical effect.
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About the authors
Alana O. Agnaeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: dr.agnaeva@gmail.com
ORCID iD: 0000-0001-8978-3221
SPIN-code: 1130-8280
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgOlesya N. Bespalova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: shiggerra@mail.ru
ORCID iD: 0000-0002-6542-5953
SPIN-code: 4732-8089
Scopus Author ID: 57189999252
ResearcherId: D-3880-2018
MD, Dr. Sci. (Med.)
Russian Federation, Saint PetersburgDmitry I. Sokolov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: falcojugger@yandex.ru
ORCID iD: 0000-0002-5749-2531
SPIN-code: 3746-0000
Scopus Author ID: 14020604500
ResearcherId: E-9050-2014
Dr. Sci. (Biol.)
Russian Federation, Saint PetersburgValentina A. Mikhailova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mva_spb@mail.ru
ORCID iD: 0000-0003-1328-8157
SPIN-code: 1749-5100
Scopus Author ID: 55598998100
ResearcherId: L-3245-2015
Cand. Sci. (Biol.)
Russian Federation, Saint PetersburgSergey V. Chepanov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: chepanovsv@gmail.com
ORCID iD: 0000-0001-6087-7152
SPIN-code: 6642-6837
Scopus Author ID: 56399329700
ResearcherId: M-3471-2015
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgSergey A. Selkov
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: selkovsa@mail.ru
ORCID iD: 0000-0003-1560-7529
SPIN-code: 7665-0594
Scopus Author ID: 6507854443
ResearcherId: G-2059-2014
MD, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation
Russian Federation, Saint PetersburgIgor Yu. Kogan
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
SPIN-code: 6572-6450
Scopus Author ID: 56895765600
ResearcherId: P-4357-2017
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, Saint PetersburgReferences
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