Cytokins as the markers for non-invasive diagnosis of pelvic endometriosis

Cover Page

Abstract


To date, pelvic endometriosis is one of the most widespread gynecological disorders in the women of reproductive age. It has been known that pelvic endometriosis is a progressive disease occuring on the background of chronic estrogen-dependent inflammatory response in the lesser pelvis. One of the key element of the pathogenesis of endometriosis is a disfunction of the immune system at both the local and systemic levels. In recent years an upward trend in the number of infiltrative forms has been noted. In relation to the pronounced adhesive process as well as presence of the endometrioid infiltration the risk of complications during surgery increases. Furthermore, aforementioned conditions can lead to subsequent longer period of rehabilitation and additional surgical interventions. Thereby, the markers for non-invasive diagnosis acquire the leading role in the diagnosis of pelvic endometriosis, analysis of the levels of which may yield a relatively complete picture of the extent of the lesions and adress the issue of the need for surgical treatment (especially repeated) timely. The most pertinent is the assessment of the levels of pro- and anti-inflammatory cytokines, the activity of natural killer cells as well as the factors of adhesion and proliferation. The article discusses the diagnostic value of interleukins IL6, IL2, IL33, IL22, transforming growth factor (TGF), vascular endothelial growth factor (VEGF), chemokine MCP1 as well as others for the non-invasive diagnosis of the disease. On the basis of the data presented it may be concluded that the comprehensive assessment of the several cytokines is required for more accurate and timely diagnosis and determining the severity of pelvic endometriosis.

Full Text

Restricted Access

About the authors

Marya Igorevna Yarmolinskaya

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: m.yarmolinskaya@gmail.com
prof. Department of obstetrics and gynecology

Dmitry Zurabovich Tsitskarava

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: tsitsskarava@yandex.ru
postgraduate student. Department of operative gynecology

Sergey Alekseevich Selkov

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: selkovsa@mail.ru
Doctor of medical sciences, head of the laboratory of immunology

References

  1. Айламазян Э. К., ред. Гинекология от пубертата до постменопаузы. Практическое руководство для врачей. М.: МЕДпресс-информ; 2007.
  2. Баскаков В. П. Клиника и лечение эндометриоза. Л.: Медицина; 1990.
  3. Кетлинский С. А., Симбирцев А. С. Цитокины. Монография. СПб.: Фолиант; 2008.
  4. Павлов Р. В., Сельков С. А. Особенности популяционного состава и функциональной активности клеток перитонеальной жидкости у женщин с наружным генитальным эндометриозом. Журнал акушерства и женских болезней. 2008; LVII (3): 67-71.
  5. Павлов Р. В. Клинико-экспериментальное обоснование использования иммуномодуляторов комплексной терапии наружного генитального эндометриоза. Автореф. дис… д-р. мед. наук. СПб.; 2009.
  6. Соколов Д. И., Кондратьева П. Г., Ярмолинская М. И., Крамарева Н. Л., Селютин А. В., Рулев В. В., Ниаури Д. А., Сельков С. А. Содержание хемокинов и цитокинов в перитонеальной жидкости больных наружным менитальным эндометриозом различной степени тяжести. Медицинская иммунология. 2007; 9 (1): 85-90.
  7. Ярмолинская М. И. Генитальный эндометриоз: влияние гормональных, иммунологических и генетических факторов на развитие, особенности течения и выбор терапии. Автореф. дис… д-р. мед. наук. СПб.; 2009.
  8. Acien P., Velasco I., Acien M., Quereda F. Treatment of endometriosis with transvaginal ultrasound-guided drainage and recombinanat interleukin-2 left in the cysts: a third clinical trial. Gynecol Obstet Invest. 2010; 69 (3): 203-11.
  9. Bertschi D., McKinnon B. D., Evers J., Bersinger N. A., Mueller M. D. Enhanced inflammatory activity of endometriotic lesions from the rectovaginal septum. Mediators Inflamm. 2013. Published online 2013 Dec doi: 10.1155/2013/450950.
  10. Bourlev V., Larsson A., Olovsson M. Elevated levels of fibroblast growth factor-2 in serum from women with endometriosis. Am. J. Obstet. Gynecol. 2006; 194 (3): 755-9.
  11. Carmona F., Chapron C., Martínez-Zamora M. Á., Santulli P., Rabanal A., Martínez-Florensa M., Lozano F., Balasch J. Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6. J. Reprod. Immunol. 2012; 95 (1-2): 80-6.
  12. Deura I., Harada T., Taniquichi F., Iwabe M., Terakawa N. Reduction of estrogen production by interleukin-6 in a human granulosa tumor cell line may have implications for endometriosis-associated infertility. Fertil. Steril. 2005; 83 (suppl. 1): 1086-92.
  13. Drosdzol-Cop A., Skrzypulec-Plinta V. Selected cytokines and glycodelin A levels in serum and peritoneal fluid in girls with endometriosis. J. Obstet. Gynaecol. Res. 2012; 38 (10): 1245-53.
  14. Elgafor E., Sharkwy I. A. Combination of non-invasive and semi-invasive tests for diagnosis of minimal to mild endometriosis. Arch. Gynecol. Obstet. 2013; 288 (4): 793-7.
  15. Fan Y., Chen B. L., Ma X. D., Su M. Q. Detection of expression of endometriosis-related cytokine and their receptor genes by cDNA microarray technique. Xi Bao, Yu Fen, Zi Mian, Yi Xue, Za Zhi. 2005; 21 (4): 489-92.
  16. Gmyrek G. B., Sieradzka U., Goluda M., Gabryś M., Sozański R., Jerzak M., Zbyryt I., Chrobak A., Chełmońska-Soyta A. Differential flow cytometric detection of intracellular cytokines in peripheral and peritoneal mononuclear cells of women with endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008; 137 (1): 67-76.
  17. Guo Y., Chen Y., Liu L. B., Chang K. K., Li H., Li M. Q., Shao J. IL-22 in the endometriotic milieu promotes the proliferation of endometrial stromal cells via stimulating the secretion of CCL2 and IL-8. Int. J. Clin. Exp. Pathol. 2013; 6 (10): 2011-20.
  18. Hassa H., Tanir H. M., Tekin B., Kirilimaz S. D., Sahin Mutlu F. Cytokine and immune cell levels in peritoneal fluid and pereipheral blood of women with early and late-staged endometriosis. Arch. Gynecol. Obstet. 2009; 279 (6): 891-5.
  19. Hayrabedyan S., Kyurkchiev S., Kehayov I. FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis. J. Reprod. Immunol. 2005; 67 (1-2): 87-101.
  20. Huang J. C., Papasakelariou C., Dawood M. Y. Epidermal growth factor and basic fibroblast growth factor in peritoneal fluid of women with endometriosis. Fertil. Steril. 1996; 65 (5): 931-4.
  21. Jee B. C., Suh C. S., Kim S. H., Moon S. Y. Serum soluble CD163 and interleukin-6 levels in women with ovarian endometriomas. Gynecol. Obstet. Invest. 2008; 66 (1): 47-52.
  22. Kalu E., Sumar N., Giannopoulos T., Patel P., Croucher C., Sherriff E., Bansal A. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. J. Obstet. Gynecol. Res. 2007; 33 (4): 490-5.
  23. Kocbek V., Vouk K., Bersinger N. A., Mueller M. D., Lanišnik Rižner T. Panels of cytokines and other secretory proteins as potential biomarkers of ovarian endometriosis. J. Mol. Diagn. 2015;17 (3): 325-34.
  24. Koippallil Gopalakrishan Nair A. R., Pandit H., Warthy N., Madan T. Endometriotic mesenchymal stem cells exhbit a distinct immune phenotype. Int. Immunol. 2015; 27 (4): 195-204.
  25. Komiyama S., Aoki D., Komiyama M., Nozawa S. Local activation of TGF-beta1 at endometriosis sites. J. Reprod. Med. 2007; 52 (4): 306-12.
  26. Li C. L., Leng J. H., Li M. H., Shi J. H., Jia S. Z., Lang J. H. Expressions and roles of TGFβ/Smad signal pathway in peritoneum of endometriosis. Zhonghua Fu Chan Ke Za Zhi. 201; 46 (11): 826-30.
  27. Martínez S., Garrido N., Coperias J. L., Pardo F., Desco J., García-Velasco J. A., Simón C., Pellicer A. Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. Him. Reprod. 2007; 22 (3): 836-42.
  28. Mei J., Xie X. X., Li M. Q., Wei C. Y., Jin L. P., Li D. J., Zhu X. Y. Indoleamine 2,3-dioxygenase-1 (IDO1) in human endometrial stromal cells induces macrophage tolerance through interleukin-33 in the progression of endometriosis. Int. J. Clin. Exp. Pathol. 2014; 7 (6): 2743-53.
  29. Mihalyi A., Gevaert O., Kyama C. M., Simsa P., Pochet N., De Smet F., De Moor B., Meuleman C., Billen J., Blanckaert N., Vodolazkaia A., Fulop V., D'Hooghe T. M. Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers. Hum. Reprod. 2010; 25 (3): 654-64.
  30. Mizumoto Y. Changes in NK activities and TGF- beta concentrations in the peritoneal cavity in endometriosis and their interaction related with infertility. Nihon Sanka Fujinka Gakkai Zasshi. 1996;48 (6): 378-9.
  31. Otman Eel-D., Hornung D., Salem H. T., Khalifa E. A., El- Metwally Th., Al-Hendy F. Serum cytokines as biomarkers of nonsurgical prediction of endometriosis. Eur. J. Obstet. Gynecological Reprod. Biol. 2008; 137 (2): 240-6.
  32. Practice committee of the American Society for Reproductive Medicine, 2004.
  33. Punnonen J., Teisala K., Ranta H., Bennett B., Punnonen R. Increased levels of interleukin-6 and interleukin-10 in the peritoneal fluid of patients with endometriosis. Am. J. Obstet. Gynecol. 1996; 174 (5): 1522-6.
  34. Querda F., Bermejo R., Velasco I., Campos A., Acien P. The effect of intraperitoneal interleukin-2 on surgically induced endometriosis in rats. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008; 136 (2): 243-8.
  35. Sacco K., Portelli M., Pollacco J., Schembri-Wismayer P., Calleja-Agius J. The role of prostaglandin E2 in endometriosis. Gynecol. Endocrinol. 2012; 28 (2): 134-8.
  36. Saito A., Osuga Y., Yoshino O., Takamura M., Hirata T., Hirota Y., Koga K., Harada M., Takemura Y., Yano T., Taketani Y. TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6. Hum. Reprod. 2011; 26 (7): 1892-8.
  37. Santulli P., Borghese B., Chouzenoux S., Vaiman D., Borderie D., Streuli I., Goffinet F., de Ziegler D., Weill B., Batteux F., Chapron C. Serum and peritoneal interleukin-33 levels are elevated in deeply infiltrating endometriosis. Hum. Reprod. 2012; 27 (7): 2001-9.
  38. Santulli P., Borghese B., Chouzenoux S., Streuli I., Borderie D., de Ziegler D., Weill B., Chapron C., Batteux F. Interleukin-19 and interleukin-22 serum levels are decreased in patients with ovarian endometrioma. Fertil. Steril. 2013; 99 (1): 219-6.
  39. Shinohara A., Kutsukake M., Takahashi M., Kyo S., Tachikawa E., Tamura K. Protease-activated receptor-stimulated interleukin-6 expression in endometriosis-like lesions in an experimental mouse model of endometriosis. J. Pharmacol. Sci. 2012; 119 (1): 40-51.
  40. Skrzypcazk J., Szczepanska M., Puk E., Kamieniczna M., Kurpisz M. Peritoneal fluid cytokines and slICAM-1 in minimal endometriosis: search for discriminating factors between infertility and/or endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005; 122 (1): 95-103.
  41. Umezawa M., Sakata C., Tanaka N., Kudo S., Tabata M., Takeda K., Ihara T., Sugamata M. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Cytokine. 2008; 43 (2): 105-9.
  42. Velasco I., Quereda F., Bermejo R., Campos A., Acien P. Intraperitoneal recombinant interleukin-2 acgtivates leukocytes in rat endometriosis. J. Reprod. Immunol. 2007; 74 (1-2): 124-32.
  43. Velasco I., Acien P., Campos A., Acirn M. I., Ruiz-Macia E. Interleukin - 6 and other soluble factors in peritoneal fkuid and endometriomas and their relation to pain and aromatase expression. J. Reprod. Immenol. 2010; 84 (2): 199-205.
  44. Wickiewicz D., Chrobak A., Gmyrek G. B., Halbersztadt A., Gabryś M. S., Goluda M., Chełmońska-Soyta A. Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis. Arch. Gynecol. Obstet. 2013; 288 (4): 805-14.
  45. Young V. J., Brown J. K., Maybin J., Saunders P. T., Duncan W. C., Horne A. W. Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J. Clin. Endocrinol. Metab. 2014; 99 (9): 3450-9.
  46. Arici A., Oral E., Attar E., Tazuke S. I., Olive D. L. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and itsmodulation of expression in mesothelial cells. Fertil. Steril. 1997; 67 (6): 1065-72.
  47. Somigliana E., Viganò P., Candiani M., Felicetta I., Di Blasio A. M., Vignali M. Use of serum-soluble intercellular adhesion molecule-1 as a new marker of endometriosis. Fertil. Steril. 2002; 77 (5): 1028-31.

Statistics

Views

Abstract - 486

PDF (Russian) - 326

Cited-By


PlumX


Copyright (c) 2015 Yarmolinskaya M.I., Tsitskarava D.Z., Selkov S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies