Cytokins as the markers for non-invasive diagnosis of pelvic endometriosis

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To date, pelvic endometriosis is one of the most widespread gynecological disorders in the women of reproductive age. It has been known that pelvic endometriosis is a progressive disease occuring on the background of chronic estrogen-dependent inflammatory response in the lesser pelvis. One of the key element of the pathogenesis of endometriosis is a disfunction of the immune system at both the local and systemic levels. In recent years an upward trend in the number of infiltrative forms has been noted. In relation to the pronounced adhesive process as well as presence of the endometrioid infiltration the risk of complications during surgery increases. Furthermore, aforementioned conditions can lead to subsequent longer period of rehabilitation and additional surgical interventions. Thereby, the markers for non-invasive diagnosis acquire the leading role in the diagnosis of pelvic endometriosis, analysis of the levels of which may yield a relatively complete picture of the extent of the lesions and adress the issue of the need for surgical treatment (especially repeated) timely. The most pertinent is the assessment of the levels of pro- and anti-inflammatory cytokines, the activity of natural killer cells as well as the factors of adhesion and proliferation. The article discusses the diagnostic value of interleukins IL6, IL2, IL33, IL22, transforming growth factor (TGF), vascular endothelial growth factor (VEGF), chemokine MCP1 as well as others for the non-invasive diagnosis of the disease. On the basis of the data presented it may be concluded that the comprehensive assessment of the several cytokines is required for more accurate and timely diagnosis and determining the severity of pelvic endometriosis.

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About the authors

Marya Igorevna Yarmolinskaya

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

prof. Department of obstetrics and gynecology

Dmitry Zurabovich Tsitskarava

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

postgraduate student. Department of operative gynecology

Sergey Alekseevich Selkov

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Doctor of medical sciences, head of the laboratory of immunology


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Copyright (c) 2015 Yarmolinskaya M.I., Tsitskarava D.Z., Selkov S.A.

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