Email this article Evaluation of survivin expression in the endometrium and endometriotic lesions in patients with genital endometriosis, type 1 diabetes mellitus and their comorbidity
- Authors: Andreeva N.Y.1, Yarmolinskaya M.I.1, Misharina E.V.1, Tolibova G.K.1, Semenova V.O.1
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Affiliations:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Issue: Vol 72, No 3 (2023)
- Pages: 5-13
- Section: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/345406
- DOI: https://doi.org/10.17816/JOWD345406
- ID: 345406
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Abstract
BACKGROUND: The prevalence of external genital endometriosis is high, yet there is insufficient understanding of its etiology and pathogenesis. This coupled with the challenges posed by its diagnosis and treatment, and its co-occurrence with type 1 diabetes mellitus, underscores the significance of this issue.
AIM: The aim of this study was to evaluate the expression of survivin in the eutopic endometrium, endometriotic lesions, and their concomitant conditions in patients with external genital endometriosis and type 1 diabetes mellitus.
MATERIALS AND METHODS: This study enrolled 43 female patients of reproductive age who were divided into four groups. The main group (n = 17) included women with surgically and histologically confirmed external genital endometriosis combined with type 1 diabetes mellitus. The external genital endometriosis group (n = 9) comprised women with isolated external genital endometriosis, while the type 1 diabetes mellitus group (n = 6) included patients with type 1 diabetes mellitus only. Finally, the control group (n = 6) consisted of women without any gynecological pathology. Biological specimens were collected during the follicular phase of the menstrual cycle, and morphological examination was carried out through histological and immunohistochemical evaluation of the endometrium and endometrioid heterotopias. Statistical analysis of the data was performed using the Jamovi software program, with statistical significance defined as p < 0.05.
RESULTS: Our findings indicate that patients with external genital endometriosis and comorbid type 1 diabetes mellitus exhibit a statistically significant increase in survivin expression in the endometrium compared to the control group or patients with type 1 diabetes mellitus only. However, no significant difference was observed in survivin expression in endometriotiс lesions between patients with external genital endometriosis and those with external genital endometriosis combined with type 1 diabetes mellitus.
CONCLUSIONS: The data obtained suggest the role of survivin in the pathogenesis of external genital endometriosis, regardless of the presence of type 1 diabetes mellitus.
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About the authors
Nelly Yu. Andreeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: nelly8352@yahoo.com
ORCID iD: 0000-0002-1928-1266
SPIN-code: 3355-2646
MD
Russian Federation, Saint PetersburgMaria I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN-code: 3686-3605
Scopus Author ID: 7801562649
ResearcherId: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
Russian Federation, Saint PetersburgElena V. Misharina
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mishellena@gmail.com
ORCID iD: 0000-0002-0276-7112
SPIN-code: 7350-5674
Scopus Author ID: 57200069538
ResearcherId: K-2720-2018
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgGulrukhsor Kh. Tolibova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: gulyatolibova@mail.ru
ORCID iD: 0000-0002-6216-6220
SPIN-code: 7544-4825
Scopus Author ID: 23111355700
ResearcherId: Y-6671-2018
MD, Dr. Sci. (Med)
Russian Federation, Saint PetersburgValeriia O. Semenova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: pyankova.valeriia@rambler.ru
ORCID iD: 0000-0002-9101-1981
SPIN-code: 1422-8060
Scopus Author ID: 57863306500
ResearcherId: HKF-5961-2023
MD
Russian Federation, Saint PetersburgReferences
- Yarmolinskaya MI. Ailamazyan EK. Genital endometriosis — different facets of the issue. Saint Petersburg: Eco-Vector; 2017. (In Russ.)
- Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis. Endocr Rev. 2019;40(4):1048–1079. doi: 10.1210/er.2018-00242
- Shafrir AL, Farland LV, Shah DK, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018;(51):1–15. doi: 10.1016/j.bpobgyn.2018.06.001
- Hemmert R, Schliep KC, Willis S, et al. Modifiable life style factors and risk for incident endometriosis. Paediatr Perinat Epidemiol. 2019;33(1):19–25. doi: 10.1111/ppe.12516
- Sinaii N, Cleary SD, Ballweg ML, et al. High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod. 2002;17(10):2715–2724. doi: 10.1093/humrep/17.10.2715
- Mormile R, Vittori G. Type 1 diabetes in women with endometriosis: what is the risk of occurrence? J Pediatr Endocrinol Metab. 2013;26(9–10):1007–1008. doi: 10.1515/jpem-2013-0134
- Shafrir AL, Palmor MC, Fourquet J, et al. Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women. Am J Reprod Immunol. 2021;86(1). doi: 10.1111/aji.13404
- Wu X, Zhang Q, Wang X, et al. Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS One. 2012;7(8). doi: 10.1371/journal.pone.0041976
- Misharina EV, Yarmolinskaya MI, Ivaschenko TE, et al. The role of survivin in the pathogenesis of genital endometriosis, current application possibilities (literature review). Gynecology. 2020;22(6):11–15. (In Russ.) doi: 10.26442/20795696.2020.6.200486
- Fujino K, Ueda M, Takehara M, et al. Transcriptional expression of survivin and its splice variants in endometriosis. Mol Hum Reprod. 2006;12(6):383–388. doi: 10.1093/molehr/gal042
- Watanabe A, Taniguchi F, Izawa M, et al. The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis. Hum reprod. 2009;24(12):3172–3179. doi: 10.1093/humrep/dep305
- Mori T, Ito F, Matsushima H, et al. G protein-coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis. Fertil Steril. 2015;103(5). doi: 10.1016/j.fertnstert.2015.01.026
- Konno R, Yamakawa H, Utsunomiya H, et al. Expression of survivin and Bcl-2 in the normal human endometrium. Mol Hum Reprod. 2000;6(6):529–534. doi: 10.1093/molehr/6.6.529
- Tarkowski R, Wojcierowski J, Polak G, et al. Ekspresja genu surviviny w prawidłowym i rozrostowym endometrium [Expression of the survivin gene in normal and hyperplastic endometrium]. Ginekol Pol. 2000;71(9):1226–1229.
- Lehner R, Enomoto T, McGregor JA, et al. Correlation of survivin mRNA detection with histologic diagnosis in normal endometrium and endometrial carcinoma. Acta Obstet Gynecol Scand. 2002;81(2):162–167. doi: 10.1034/j.1600-0412.2002.810213.x
- Nabilsi NH, Broaddus RR, McCampbell AS, et al. Sex hormone regulation of survivin gene expression. J Endocrinol. 2010;207(2):237–243. doi: 10.1677/JOE-10-0128
- Cho M, Lee OH, Chang EM, et al. BIRC5 expression is regulated in uterine epithelium during the estrous cycle. Genes. 2020;11(3). doi: 10.3390/genes11030282
- Erkanli S, Kayaselcuk F, Kuscu E, et al. Expression of survivin, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium. Int J Gynecol Cancer. 2006;16(3):1412–1418. doi: 10.1111/j.1525-1438.2006.00541.x
- Vaskivuo TE, Stenbäck F, Karhumaa P, et al. Apoptosis and apoptosis-related proteins in human endometrium. Mol Cell Endocrinol. 2000;165(1–2):75–83. doi: 10.1016/s0303-7207(00)00261-6
- Bianco B, Filipchiuk C, Christofolini DM, et al. The role of survivin in the pathogenesis of endometriosis. Minerva Med. 2020;111(1):21–32. doi: 10.23736/S0026-4806.19.06358-4
- Zhang H, Li M, Zheng X, Sun Y, Wen Z, Zhao X. Endometriotic stromal cells lose the ability to regulate cell-survival signaling in endometrial epithelial cells in vitro. Mol Hum Reprod. 2009;15(10):653–663. doi: 10.1093/molehr/gap069
- Connell CM, Colnaghi R, Wheatley SP. Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem. 2008;283(6):3289–3296. doi: 10.1074/jbc.M704461200
- Stauber RH, Rabenhorst U, Rekik A, et al. Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal. Traffic. 2006;7(11):1461–1472. doi: 10.1111/j.1600-0854.2006.00486.x
- Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis based diagnosis and treatment of endometriosis. Front Endocrinol. 2021;12. doi: 10.3389/fendo.2021.745548
- Zhu B, Qu S. The Relationship between diabetes mellitus and cancers and its underlying mechanisms. Front Endocrinol. 2022;13. doi: 10.3389/fendo.2022.800995
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