Vulvar dystrophies: a modern view of the problem

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Abstract

This article overviews modern literature data on vulvar dystrophies. The increase in the number of patients with dystrophic diseases of the vulva, a pronounced tendency towards rejuvenation, the complexity of diagnosis, frequent recurrence of the disease and low effectiveness of therapy make this issue extremely urgent. Until now, morphologists have not developed a single classification, and among clinicians, a specific etiopathogenetic concept of development of vulvar dystrophies has not been determined. There are many theories of the disease development. The process starts asymptomatically and is not diagnosed in a timely manner, and due to the localization in the intimate area, it is characterized by low circulation and an increase in the number of neglected cases. Only a comprehensive, timely started treatment with the right choice of drugs and methods of activating reparative processes will prevent development of the disease and reduce the duration of the main symptoms and the likelihood of relapses, exacerbations, and complications.

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About the authors

Olga Yu. Tsygankova

Omsk State Medical University

Author for correspondence.
Email: olts74@mail.ru
ORCID iD: 0000-0002-3553-055X
SPIN-code: 7863-9118
Scopus Author ID: 57219993072

MD, Cand. Sci. (Med.)

Russian Federation, Omsk

Elena N. Kravchenko

Omsk State Medical University

Email: kravchenko.en@mail.ru

MD, Dr. Sci. (Med.), Professor

Russian Federation, Omsk

Maria V. Tsygankova

Omsk State Medical University

Email: tsygankovva98@mail.ru
ORCID iD: 0000-0003-4424-0850
Russian Federation, Omsk

References

  1. Sakhautdinova IV, Popov OS, Simakova EL. Modern view on the problem of etiology, pathogenesis and therapy of degenerative diseases of the vulva. Medicinskij vestnik Bashkortostana. 2015;10(6):84−88. (In Russ.)
  2. Porsokhonova DF, Rakhmatullaeva SN, Yakubovich AI, et al. Risk factors of distrophic diseases of vulvae: clinical-epidemiological research. Arhiv akusherstva i ginekologii im. V.F. Snegireva. 2017;4(3):154−158. (In Russ.). doi: 10.18821/2313-8726-2017-4-3-154-158
  3. Apolikhina IA, Sokolova AV, Gumova ZD. External genitalia lichen sclerosus and main causes, clinic, diagnostics and treatment. Medicinskij opponent. 2018;(2):77−82. (In Russ.)
  4. Porsokhonova DF, Medzhitova AM. The principal directions in treatment of degenerative diseases of vulva. Klinicheskaja dermatologija i venerologija. 2015;(5):11−15. (In Russ.)
  5. Galikhanova EE, Kozlov VK, Khromova AM. Luminescence microscopy in diagnostics of urogenital candidiasis of patients with distrophic diseases of vulvae and vagine. Prakticheskaja medicina. 2011;(2(49):43−45. (In Russ.)
  6. Rusakevich PS, Grishanovich RV, Plavskiy VYu. Possibilities of photodynamic therapy with local use of photosensitizers in neurodystrophic vulvae diseases, cervical ectopia and metaplasia. Onkologicheskii zhurnal. 2010;4(1(13):47−53. (In Russ.)
  7. McPherson T, Cooper S. Vulval lichen sclerosus and lichen planus. Dermatol Ther. 2010;23(5):523−532. doi: 10.1111/j.1529-8019.2010.01355.x
  8. Casabona F, Priano V, Vallerino V, et al. New surgical approach to lichen sclerosus of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration. Plast Reconstr Surg. 2010;126(4):210e−211e. doi: 10.1097/prs.0b013e3181ea9386
  9. Makarov IO, Chulkova EA, Sheshukova NA, Makarova II. Not tumoral diseases of vulva. Akusherstvo, ginekologiya i reproduktsiya. 2012;6(2):14−17. (In Russ.)
  10. Shier M, El-Khatib S. Vulvar lichen sclerosus. J Obstet Gynaecol Can. 2010;32(10):929−930. doi: 10.1016/s1701-2163(16)34676-x
  11. Thorstensen KA, Birenbaum DL. Recognition and management of vulvar dermatologic conditions: lichen sclerosus, lichen planus, and lichen simplex chronicus. J Midwifery Womens Health. 2012;(57 Pt 3):260−275. doi: 10.1111/j.1542-2011.2012.00175.x
  12. .Chernova NI, Arutyunyan E. Current aspects of treatment in patients with dystrophy and atrophy of the intimate area. What is new? Rossiiskii vestnik akushera-ginekologa. 2018;(3):95−98. doi: 10.17116/rosakush201818295-98. (In Russ.)
  13. Makarov OV, Khashukoeva AZ, Оtdelnova OB, Kupeeva ES. Our experience in treating gynaecological diseases with photodynamic therapy. Lazernaya meditsina. 2012;16(2):40−44. (In Russ.)
  14. Li GT, Guo SZ, Liu YJ, Yang B. Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder. Clin Exp Obstet Gynecol. 2014;41(2):174−176.
  15. Pamfamirov YK, Zabolotnov VA, Kucherenko YA, et al. Vulvar denervation in dystrophy processes treatment. Zdorov’e zhenshchiny. 2012;4(70):166. (In Russ.)
  16. Grigoriadis C, Hassiakos D, Bakas P, et al. Effect of gonadal steroid receptors alterations on the pathophysiology of pelvic organ prolapse and urinary incontinence. Minerva Ginecol. 2016;68(1):37−42.
  17. Jarząbek-Bielecka G, Wilczak M, Potasińska-Sobkowska A, et al. Overweight, obesity and female sexuality in perimenopause: a preliminary report. Prz Menopauzalny. 2015;14(2):97−104. doi: 10.5114/pm.2015.52151
  18. Nowakowska I, Rasińska R, Głowacka M. Analysis of relationships between perimenopausal symptoms and professional functioning and life satisfaction. Subjective perception of the dependence in women aged 40. Med Pr. 2015;66(3):351−358. doi: 10.13075/mp.5893.00243
  19. Miyagawa S, Sato M, Sudo T, et al. Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina. Oncogene. 2015;19(34 Pt 8):1035−1043. doi: 10.1038/onc.2014.62
  20. Galikhanova EE. Osobennosti klinicheskogo techeniya i lecheniya kandidoznykh infektsii u zhenshchin s distroficheskimi zabolevaniyami vul’vy i vlagalishcha [dissertation abstract]. Moscow; 2012 [cited 20 Aug 2021]. Available from: https://www.dissercat.com/content/osobennosti-klinicheskogo-techeniya-i-lecheniya-kandidoznoi-infektsii-u-zhenshchin-s-distrof. (In Russ.)
  21. Reutskaya MA, Kulinich SI. Vulvar diseases and their interrelation with genital infections. Sibirskii meditsinskii zhurnal. 2010;97(6):239−242. (In Russ.)
  22. Batyrshina SV, Galichanova EE, Akberova DR. Candidal and papillomavirus infection in women with inflammatory and dystrophic diseases of the vulva and vagina. Obstetrics and Gynecology. 2012;(9):175−180. (In Russ.)
  23. Kreuter A, Kryvosheyeva Y, Terras S, et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol. 2013;(93 Pt 2):238–241. doi: 10.2340/00015555-1512
  24. Kiyohara T, Satoh S, Kumakiri M. Eosinophilic spongiosis in vulvar lichen sclerosus. J Dermatol. 2013;40(2)148−149. doi: 10.1111/1346-8138.12044
  25. Chang JC, Blake DG, Leung BV, Plaza JA. Langerhans cell histiocytosis associated with lichen sclerosus of the vulva: case report and review of the literature. J Cutan Pathol. 2013;40(2):279−283. doi: 10.1111/cup.12051
  26. Osiecka BJ, Nockowski P, Jurczyszyn K, Ziolkowski P. Photodynamic therapy of vulvar lichen sclerosus et atrophicus in a woman with hypothyreosis – сase report. Photodiagnosis Photodyn Ther. 2012;9(2):186−188. doi: 10.1016/j.pdpdt.2012.02.002
  27. Nasca MR, Lacarrubba F, Micali G. Human papillomavirus infection and lichen sclerosus: coincidence or link? Int J Dermatol. 2018;57(5):617–618. doi: 10.1111/ijd.13933
  28. Sherman V, McPherson T, Baldo M, et al. The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study. J Eur Acad Dermatol Venereol. 2010;24(9):1031–1034. doi: 10.1111/j.1468-3083.2010.03572.x
  29. Aranda J, Carder KR. Diagnosis and treatment of diseases of the vulva from the standpoint of the dermatologist. Reproduktivnoe zdorov’e detei i podrostkov. 2012;(3):19−32. (In Russ.)
  30. Khashukoeva AZ, Kupeeva ES, Narimanova MR. Fotodinamicheskaya terapiya distroficheskikh zabolevanii vul’vy. Fotodinamicheskaya terapiya i fotodiagnostika. 2013;2(3):53−54. (In Russ.)
  31. Lee A, Bradford J, Fischer G. Long-term management of adult vulvar lichen sclerosus: A prospective cohort study of 507 women. JAMA Dermatol. 2015;151(10):1061−1067. doi: 10.1001/jamadermatol.2015.0643
  32. Manolova G, Pehlivanov G, Bakadzhiev I, et al. Lichen sclerosus-clinical and therapeutic aspects. Akush Ginekol (Sofiia). 2014;53(1):35–39.
  33. Lifits-Podorozhansky YM, Podorozhansky Y, Hoffstetter S, Gavard JA. Role of vulvar care guidelines in the initial management of vulvar complaints. J Low Genit Tract Dis. 2012;16(2):88−91. doi: 10.1097/lgt.0b013e318232fd9a
  34. De Grande Curi D, Roa CL, de Aguiar LM, et al. Vulvar lichen sclerosus: description of 5 cases successfully treated with the 2,940 nm Erbium-YAG laser. Surgical and Cosmetic Dermatology. 2017;9(3):265–268. doi: 10.5935/scd1984-8773.2017931027
  35. Simakova EL, Sakhautdinova IV, Muslimova SYu. Novel technologies with the use of allogeneic biomaterials in the therapy of scleroatrophic lichen. Onkoginekologiya. 2016;(2):59−64. (In Russ.)
  36. Lev-Sagie A. Vulvar and vaginal atrophy: physiology, clinical presentation, and treatment considerations. Clin Obstet Gynecol. 2015;58(3):476−491. doi: 10.1097/grf.0000000000000126
  37. Murphy R. Lichen sclerosus. Dermatol Clin. 2010;28(4):707−715. doi: 10.1016/j.det.2010.07.006
  38. Vtorenko VI, Yezhov VV, Yelkanova EE, Saljuk VA. A case of treating hyperplastic vulva dystrophy with laser shockwave destruction (a practical experience). Lazernaya meditsina. 2015;19(2):42−43. (In Russ.)
  39. Makarov OV, Khashukoeva AZ, Оtdelnova OB, Kupeeva ES. Fotodinamicheskaya terapiya kak perspektivnyi metod lecheniya distroficheskikh zabolevanii vul’vy. Lechashchii vrach. 2011;(11):28−30. (In Russ.)
  40. Kupeeva ES. Fotodinamicheskaya terapiya s ispol’zovaniem fotosensibilizatora fotoditazin v lechenii distroficheskikh zabolevanii vul’vy. [dissertation abstract] Moscow; 2014 [cited 23 Aug 2021]. Available from: https://www.dissercat.com/content/fotodinamicheskaya-terapiya-s-ispolzovaniem-fotosensibilizatora-fotoditazin-v-lechenii-distr. (In Russ.)
  41. Reutskaya MA. Vulvar diseases and their interrelation with genital infection. Sibirskii meditsinskii zhurnal. 2011;105(6):277−279. (In Russ.)
  42. Pinelli S, D’Erme AM, Lotti T. Management of sexual dysfunction due to vulvar lichen sclerosus in postmenopausal women. Dermatol Ther. 2013;26(1):79−82. doi: 10.1111/j.1529-8019.2012.01536.x
  43. D’Antuono A, Bellavista S, Negosanti F, et al. Dermasilk briefs in vulvar lichen sclerosus: an adjuvant tool. J Low Genit Tract Dis. 2011;(15 Pt 4):287−291. doi: 10.1097/lgt.0b013e31821380a0

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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