The status of mammary glands in patients with combined hyperplasias of the organs of reproductive system after ovariectomy

E. N. Baylyuk; Байлюк Е. Н.; V. F. Semiglazov; Семиглазов В. Ф.; D. А. Niauri; Ниаури Д. А.; A. A. Soshnev; Сошнев А. А.

doi:10.17816/JOWD87525

The status of mammary glands in patients with combined hyperplasias of the organs of reproductive system after ovariectomy

Authors: Baylyuk E.N.¹^,2, Semiglazov V.F.³, Niauri D.А.⁴, Soshnev A.A.⁴
Affiliations:
1. Saint-Petersburg State University
2. Ott Research Institute
3. Research Institute of oncology
4. Saint Petersburg State University
Issue: Vol 54, No 5S (2005)
Pages: 80-81
Section: Reviews
URL: https://journals.eco-vector.com/jowd/article/view/87525
DOI: https://doi.org/10.17816/JOWD87525
ID: 87525

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mammary gland, reproductive system hyperplasia, ovariectomy

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Results. Various forms of mastopathy were found in 94% of clinical cases (63 patients). The diagnosis of mastopathy was established, according to the data of ultrasonographic examination, X-ray mammography, cytological and/or histological studies. Diffuse form of chronic cystic mastitis (DCCM) was found in 74,6% of cases, nodal form of chronic cystic mastitis - in 19% of cases (including 3 patients with atypical proliferation), in 4,8% of cases fibrous adenoma of mammary gland was found, and a single case of intraductal papilloma was observed. During surgical treatment of primary disorder 46 patients underwent mono- or bilateral ovariectomy. Surgical intervention on mammary gland was carried out as a second step. A total of 4 sectoral resections and one central resection was performed. 11 patients refused the suggested surgery. Patients received no pharmacotherapy of primary disorder. Five years later thorough clinical examination of the patients has revealed that only 56,7% of women who underwent surgery of uterine appendages retained mastopathy. Bilateral ovariectomy has led to 30% reduction of DCCM, unilateral ovariectomy has led to 24% reduction. No progression of mastopathy was found in patients with nodal form of chronic cystic mastitis and fibrous adenoma of mammary gland, regardless of type of surgery. No recurrence was found in patient with intraductal papilloma after bilateral ovariectomy. All women with intact ovaries (21 patient) had mastopathy after the five-year period. Nodal form of chronic cystic mastitis was found in 9 women with previously diagnosed DCCM, and two patients were diagnosed with carcinoma in situ. In patients who initially refused surgical intervention on mammary gland, the size of nodes has increased more than 50% during the 5 years.

Conclusions. The data above supports, that patients with CHORS should be treated as a group at a high risk of benign hyperplasias and dysplasias of mammary glands, which, in its turn, requires thorough specialized examination prior to surgical treatment of the primary disorder. When the extent of surgical operation is determined in premenopausal women, it is necessary to consider that even severe organic changes in mammary glands can resolve after surgical postmenopause. It is clear, that correct and timely surgical intervention in CHORS patients allows prevention of breast cancer.