The effect of excess body weight and obesity on the effectiveness of assisted reproductive technologies programs

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Abstract


The purpose of the study. To determine the main indicators of the effectiveness of IVF programs in over-weight and obese patients. Based on the Research Institute of obstetrics, gynecology, and reproductology D.O. Ott, we conducted an analysis involving women aged 18–39 years who were treated in the IVF program in the department of assistive technologies in infertility treatment. The study included 97 patients who met the selection criteria. The patients were categorized into three groups: group I, 33 obese women (body mass index (BMI) ≥ 30.8 kg/m2); group II, 34 overweight women (BMI = 25 to 29.9 kg/m2); and the control group, 30 normal weight patients (BMI = 18 to 24.9 kg/m2). As a result, the efficiency of ART programs decreased significantly in women of group I, owing to the weaker response of the ovaries to the stimulation of superovulation, which causes an increased gonadotropin demand to stimulate  ovulation.


Manizha R. Mahmadaliyeva

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Author for correspondence.
Email: 2563737@mail.ru

Russian Federation, St. Petersburg

Postgraduate Student, Department of Assisted Reproductive Technologies

Igor Yu. Kogan

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: iagmail@ott.ru

Russian Federation, St. Petersburg

Doctor of Medical Sciences, Professor, Scientific Secretary

Dariko A. Niauri

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: d.niauri@mail.ru

Russian Federation, St. Petersburg

Doctor of Medical Sciences, Head of the Department of Obstetrics, Gynecology and Reproduction

Irina D. Mekina

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: iagmail@ott.ru

Russian Federation, St. Petersburg

Candidate of Biological Sciences, Senior Researcher, Senior Embryologist, Department of Assistive Reproductive Technologies

Alexander M. Gzgzyan

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: iagmail@ott.ru

Russian Federation, St. Petersburg

Doctor of Medical Sciences, Professor of the Department of Obstetrics, Gynecology and Reproductology of the Medical Faculty

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Supplementary files

Supplementary Files Action
1. Fig. 1. The need for medicines of gonadotrophins for stimulation of a superovulation in cycles IVF at women with obesity, excess and normal body weight (p1, 2 < 0.01; р1, 3 < 0.01) View (86KB) Indexing metadata
2. Fig. 2. Quantity of the received oocytes in cycles IVF at women with obesity, excess and normal body weight (p1, 2 < 0.01; р1, 3 < 0.01) View (83KB) Indexing metadata
3. Fig. 3. The size of an effective dose in cycles EKO at women with obesity, excess and normal body weight (p1, 2 < 0.01; р1, 3 < 0.01) View (86KB) Indexing metadata
4. Fig. 4. Quantity of embryos of high quality at women with obesity, excess and normal body weight (p1, 2 < 0.0001; р1, 3 < 0.0001) View (84KB) Indexing metadata
5. Fig. 5. The dose spent for one embryo of high quality at women with obesity, excess and normal body weight (p1, 2 < 0.0001; р1, 3 < 0.0001) View (98KB) Indexing metadata

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Copyright (c) 2018 Mahmadaliyeva M.R., Kogan I.Y., Niauri D.A., Mekina I.D., Gzgzyan A.M.

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