Fetal adrenal cortex function in pregnancy, complicated by maternal insulin-dependent diabetes mellitus

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Abstract

Fetal adrenal cortex glucocorticoid andfetal hypophysial adrenocorticotropic function in normal pregnancy and pregnancy, complicated with maternal insulin­ dependent diabetes mellitus were examined in the present study. Statistically significant feta l hypercortisolemia was observed in pregnancies, complicated by insulin-dependent diabetes mellitus. Correlations between vascular complications o f maternal insulin-dependent diabetes mellitus and fetal cortisol andACTG levels were revealed during the investigation. Severe vascular lesions o f maternal diabetes have been associated with delayed feta l lung maturity. Fetal pulmonary maturity was significantly associated with fe ta l cortisol levels.

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About the authors

E. V. Shelaeva

Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg

A. V. Mikhailov

Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, St. Petersburg

V. L. Borodina

Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, St. Petersburg

T. I. Oparina

Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, St. Petersburg

References

Supplementary files

Supplementary Files
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1. JATS XML
2. Rice. 1. The content of total cortisol (nmol / l) in the blood of fetuses of the main groups and the comparison group. ** p <0.01 in relation to the comparison group, * p <0.05 in comparison with the first group

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3. Rice. 2. The level of ACTH (pmol / l) in the blood of fetuses of the main groups and the comparison group. * p <0.05 in relation to group I

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4. Rice. 3. The content of C-peptide in the blood of fetuses of the main groups and the comparison group. * - p <0.05 in comparison with the corresponding indicator from group I

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389
от 15.07.2002 г.



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