Hypothyroidism and early fetal demise

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Abstract


Background. The study is devoted to the evaluation of thyroid status in patients with early fetal demise.

The aim of the study was to assess the prevalence of hypothyroidism, including its subclinical forms, in patients with early fetal demise.

Materials and methods. It is an observational “case-control” retrospective study. Group I is represented by first-pregnant women with physiological on-time delivery of the healthy child (375 people). Group II consisted of 375 women who had had an episode of early fetal demise for up to 14 weeks. Laboratory and instrumental methods included assessment of TSH and anti-TPO antibodies levels and ultrasound imaging of the thyroid gland.

Results. Given TSH levels > 2.5 mU/L, the diagnosis of subclinical hypothyroidism was established in 13.1% of patients in group I and 26.4% in group II. In patients with repeated early fetal demise, the morbidity reached 48.4%.

Conclusion. Hypothyroidism can be recognized as a risk factor for early fetal demise (both the first and subsequent episodes) based on the odds ratio calculation. The odds ratio was 2.48 for early fetal demise in the presence of subclinical hypothyroidism and 2.15 for repeat episodes.


Anna A. Olina

Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Author for correspondence.
Email: olina29@mail.ru

Russian Federation, Saint Petersburg

MD, PhD, DSci (Medicine), Deputy Director for Developmen

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Supplementary files

Supplementary Files Action
1. Fig. 1. Distribution of patients in groups by TSH level View (66KB) Indexing metadata
2. Fig. 2. Distribution of patients in subgroups by TSH level View (73KB) Indexing metadata

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