Influence of Mildronatum on the “mother-placenta-fetus” system circulation with different degrees of its disorder
- Authors: Krivtsova E.I.1, Pavlova N.G.1
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Affiliations:
- D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
- Issue: Vol 48, No 5S (1999)
- Pages: 91-91
- Section: Articles
- URL: https://journals.eco-vector.com/jowd/article/view/101029
- DOI: https://doi.org/10.17816/JOWD101029
- ID: 101029
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Full Text
Abstract
Objective: Investigation of the influence of Mildronatum on hemodynamics in the “mother-placenta-fetus” system with different degrees of its circulatory disorders in 21 women in the III trimester of pregnancy.
Full Text
Objective: Investigation of the influence of Mildronatum on hemodynamics in the “mother-placenta-fetus” system with different degrees of its circulatory disorders in 21 women in the III trimester of pregnancy.
Methods: Dopplerometric study of the blood flow was performed in the umbilical artery (UmA), middle meningeal artery of the fetus and uterine arteries (UtA) before and after infusion 10% solution of mildronatum in a dose of 5,0 ml.
Results: Administration of mildronatum at the I (SDR FVW UmA=3,98±0,21; IR = 0,74±0,01) and II (SDR FVW UmA = 4,1±0,29; IR = 0,75±0,01; SDR FVW UtA = 2,87±0,35; IR = 0,63±0,03) degree of the blood flow disorder resulted in normalization of feto-placental blood flow in the UtA by 9% with the II degrees of the disorder. A reliable decrease of SDR FVW in the UmA was observed (SDR FVW UmA = 7,18±1,52; IR = 0,83±0,04, SDR FVW UmA = 4,44±0,79; IR = 0,74±0,05 respectively) as well as normalization of the cerebroplacental ratio. Blood flow in the UtA did not change.
Conclusions: Mildronatum exerts favorable influence on pathological hemodynamic changes in the “mother-placenta-fetus” system, and its efficiency is maximum in cases of significant blood flow disorders.
About the authors
E. I. Krivtsova
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg
N. G. Pavlova
D.O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences
Email: info@eco-vector.com
Russian Federation, St. Petersburg