Influence of Mildronatum on the “mother-placenta-fetus” system circulation with different degrees of its disorder

Abstract

Objective: Investigation of the influence of Mildronatum on hemodynamics in the “mother-placenta-fetus” system with different degrees of its circulatory disorders in 21 women in the III trimester of pregnancy.

Full Text

Methods: Dopplerometric study of the blood flow was performed in the umbilical artery (UmA), middle meningeal artery of the fetus and uterine arteries (UtA) before and after infusion 10% solution of mildronatum in a dose of 5,0 ml.

Results: Administration of mildronatum at the I (SDR FVW UmA=3,98±0,21; IR = 0,74±0,01) and II (SDR FVW UmA = 4,1±0,29; IR = 0,75±0,01; SDR FVW UtA = 2,87±0,35; IR = 0,63±0,03) degree of the blood flow disorder resulted in normalization of feto-placental blood flow in the UtA by 9% with the II degrees of the disorder. A reliable decrease of SDR FVW in the UmA was observed (SDR FVW UmA = 7,18±1,52; IR = 0,83±0,04, SDR FVW UmA = 4,44±0,79; IR = 0,74±0,05 respectively) as well as normalization of the cerebroplacental ratio. Blood flow in the UtA did not change.

Conclusions: Mildronatum exerts favorable influence on pathological hemodynamic changes in the “mother-placenta-fetus” system, and its efficiency is maximum in cases of significant blood flow disorders.