Autosensitization to human chorionic gonadotropin: etiology, role in reproductive loss, and approaches to therapy

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The important role of human chorionic gonadotropin in pregnancy suggests the occurrence of reproductive disorders due to the circulation of specific antibodies, especially in early pregnancy, which can lead to a cascade of pathological reactions such as implantation failure, placentation, trophoblast invasion, and ultimately fetal rejection. The lack of knowledge and the complexity of diagnosing and treating this autoimmune pathology in reproductive medicine and obstetrics negatively affects both the outcomes of each individual pregnancy and the demographic situation as a whole. This review article highlights the main ideas about the causes of human chorionic gonadotropin antibody occurrence, the pathological mechanisms, the reproductive and obstetric complications associated with human chorionic gonadotropin autoantibodies, diagnostic methods, and therapeutic approaches.

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作者简介

Daria Tkhai

Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова

Email: tkhay20@gmail.com
ORCID iD: 0000-0002-3426-5125
SPIN 代码: 6619-1805
俄罗斯联邦, Saint Petersburg

Sergey Chepanov

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: chepanovsv@gmail.com
ORCID iD: 0000-0001-6087-7152
SPIN 代码: 6642-6837
Scopus 作者 ID: 56399329700
Researcher ID: M-3471-2015

MD, Cand. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Olga Arzhanova

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: arjanova_olga@mail.ru
ORCID iD: 0000-0003-3059-9811
SPIN 代码: 7910-6039
Scopus 作者 ID: 6603489502
Researcher ID: G-6895-2015

MD, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation

俄罗斯联邦, Saint Petersburg

Olesya Bespalova

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: shiggerra@mail.ru
ORCID iD: 0000-0002-6542-5953
SPIN 代码: 4732-8089
Scopus 作者 ID: 57189999252
Researcher ID: D-3880-2018

MD, Dr. Sci. (Med.)

俄罗斯联邦, Saint Petersburg

Sergey Selkov

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

编辑信件的主要联系方式.
Email: selkovsa@mail.ru
ORCID iD: 0000-0003-1560-7529
SPIN 代码: 7665-0594
Scopus 作者 ID: 6507854443
Researcher ID: G-2059-2014

MD, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation

俄罗斯联邦, Saint Petersburg

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