电邮这篇文章 Evaluation of survivin expression in the endometrium and endometriotic lesions in patients with genital endometriosis, type 1 diabetes mellitus and their comorbidity
- 作者: Andreeva N.Y.1, Yarmolinskaya M.I.1, Misharina E.V.1, Tolibova G.K.1, Semenova V.O.1
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 72, 编号 3 (2023)
- 页面: 5-13
- 栏目: Original Research
- URL: https://journals.eco-vector.com/jowd/article/view/345406
- DOI: https://doi.org/10.17816/JOWD345406
- ID: 345406
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BACKGROUND: The prevalence of external genital endometriosis is high, yet there is insufficient understanding of its etiology and pathogenesis. This coupled with the challenges posed by its diagnosis and treatment, and its co-occurrence with type 1 diabetes mellitus, underscores the significance of this issue.
AIM: The aim of this study was to evaluate the expression of survivin in the eutopic endometrium, endometriotic lesions, and their concomitant conditions in patients with external genital endometriosis and type 1 diabetes mellitus.
MATERIALS AND METHODS: This study enrolled 43 female patients of reproductive age who were divided into four groups. The main group (n = 17) included women with surgically and histologically confirmed external genital endometriosis combined with type 1 diabetes mellitus. The external genital endometriosis group (n = 9) comprised women with isolated external genital endometriosis, while the type 1 diabetes mellitus group (n = 6) included patients with type 1 diabetes mellitus only. Finally, the control group (n = 6) consisted of women without any gynecological pathology. Biological specimens were collected during the follicular phase of the menstrual cycle, and morphological examination was carried out through histological and immunohistochemical evaluation of the endometrium and endometrioid heterotopias. Statistical analysis of the data was performed using the Jamovi software program, with statistical significance defined as p < 0.05.
RESULTS: Our findings indicate that patients with external genital endometriosis and comorbid type 1 diabetes mellitus exhibit a statistically significant increase in survivin expression in the endometrium compared to the control group or patients with type 1 diabetes mellitus only. However, no significant difference was observed in survivin expression in endometriotiс lesions between patients with external genital endometriosis and those with external genital endometriosis combined with type 1 diabetes mellitus.
CONCLUSIONS: The data obtained suggest the role of survivin in the pathogenesis of external genital endometriosis, regardless of the presence of type 1 diabetes mellitus.
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作者简介
Nelly Andreeva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: nelly8352@yahoo.com
ORCID iD: 0000-0002-1928-1266
SPIN 代码: 3355-2646
MD
俄罗斯联邦, Saint PetersburgMaria Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
Scopus 作者 ID: 7801562649
Researcher ID: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
俄罗斯联邦, Saint PetersburgElena Misharina
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: mishellena@gmail.com
ORCID iD: 0000-0002-0276-7112
SPIN 代码: 7350-5674
Scopus 作者 ID: 57200069538
Researcher ID: K-2720-2018
MD, Cand. Sci. (Med.)
俄罗斯联邦, Saint PetersburgGulrukhsor Tolibova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: gulyatolibova@mail.ru
ORCID iD: 0000-0002-6216-6220
SPIN 代码: 7544-4825
Scopus 作者 ID: 23111355700
Researcher ID: Y-6671-2018
MD, Dr. Sci. (Med)
俄罗斯联邦, Saint PetersburgValeriia Semenova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: pyankova.valeriia@rambler.ru
ORCID iD: 0000-0002-9101-1981
SPIN 代码: 1422-8060
Scopus 作者 ID: 57863306500
Researcher ID: HKF-5961-2023
MD
俄罗斯联邦, Saint Petersburg参考
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