Pathogenesis and treatment principles ocular damage by self-defense gas weapons
- Authors: Kacherovich P.A.1,2, Kulikov A.N.1, Lapina N.V.2, Bespalov A.Y.2, Krasnov K.A.2, Kharitonova N.N.1, Troyanovskiy R.L.1
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Affiliations:
- Kirov Military Medical Academy
- Golikov Research Clinical Center of Toxicology
- Issue: Vol 15, No 2 (2022)
- Pages: 55-63
- Section: Reviews
- Submitted: 30.03.2022
- Accepted: 24.06.2022
- Published: 02.10.2022
- URL: https://journals.eco-vector.com/ov/article/view/105683
- DOI: https://doi.org/10.17816/OV105683
- ID: 105683
Cite item
Abstract
The article presents the pathogenetic mechanisms of eye damage by gas self-defense weapons in detail. We discuss the mechanisms of eye damage and structural changes of the tissues after gas-trauma. The causes of these changes and the main clinical manifestations accompanying them are analyzed. We analyzed the factors, influencing the development of dystrophic changes of the ocular surface in detail. The information on various techniques for self-assistance, mutual aid and earlier specific treatment of this injury was summarized. An aqueous solution of pediphene substance promising for use is considered, which has a number of pharmacological properties that fundamentally affect the pathogenetic mechanisms of gas-weapon trauma. Its effectiveness was shown in the experiment in comparison with the control group without treatment and the group using the combined drug-dexamethasone in combination with an antibiotic.
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About the authors
Polina A. Kacherovich
Kirov Military Medical Academy; Golikov Research Clinical Center of Toxicology
Author for correspondence.
Email: polin.ka@list.ru
ORCID iD: 0000-0001-9629-5437
Lecturer of the Ophthalmology Department
Russian Federation, Saint Petersburg; Saint PetersburgAlexey N. Kulikov
Kirov Military Medical Academy
Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
SPIN-code: 6440-7706
Dr. Sci. (Med.), Professor, Head of the Department of Ophthalmology
Russian Federation, Saint PetersburgNatalia V. Lapina
Golikov Research Clinical Center of Toxicology
Email: lapina2005@inbox.ru
SPIN-code: 4385-8991
Cand. Sci. (Med.), Head of the Laboratory of Applied Toxicology and Pharmacology of the Toxicology Department
Russian Federation, Saint PetersburgAlexander Ya. Bespalov
Golikov Research Clinical Center of Toxicology
Email: bespalov_tox@mail.ru
SPIN-code: 9970-5208
Cand. Sci. (Chem.), Leading Researcher at the Laboratory of Drug Synthesis
Russian Federation, Saint PetersburgKonstantin A. Krasnov
Golikov Research Clinical Center of Toxicology
Email: krasnov_tox@mail.ru
SPIN-code: 9191-1646
Cand. Sci. (Chem.), Leading Researcher at the Laboratory of Medical Problems of Chemical Safety
Russian Federation, Saint PetersburgNatalya N. Kharitonova
Kirov Military Medical Academy
Email: natal56@mail.ru
SPIN-code: 9277-7406
Cand. Sci. (Med.), Assistant Professor of Ophthalmology Department
Russian Federation, Saint PetersburgRoman L. Troyanovskiy
Kirov Military Medical Academy
Email: rltroy@rambler.ru
SPIN-code: 1900-1622
Dr. Sci. (Med.), Professor of the Ophthalmology Department
Russian Federation, Saint PetersburgReferences
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