Pathogenesis and treatment principles ocular damage by self-defense gas weapons

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Abstract

The article presents the pathogenetic mechanisms of eye damage by gas self-defense weapons in detail. We discuss the mechanisms of eye damage and structural changes of the tissues after gas-trauma. The causes of these changes and the main clinical manifestations accompanying them are analyzed. We analyzed the factors, influencing the development of dystrophic changes of the ocular surface in detail. The information on various techniques for self-assistance, mutual aid and earlier specific treatment of this injury was summarized. An aqueous solution of pediphene substance promising for use is considered, which has a number of pharmacological properties that fundamentally affect the pathogenetic mechanisms of gas-weapon trauma. Its effectiveness was shown in the experiment in comparison with the control group without treatment and the group using the combined drug-dexamethasone in combination with an antibiotic.

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About the authors

Polina A. Kacherovich

Kirov Military Medical Academy; Golikov Research Clinical Center of Toxicology

Author for correspondence.
Email: polin.ka@list.ru
ORCID iD: 0000-0001-9629-5437

Lecturer of the Ophthalmology Department

Russian Federation, Saint Petersburg; Saint Petersburg

Alexey N. Kulikov

Kirov Military Medical Academy

Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
SPIN-code: 6440-7706

Dr. Sci. (Med.), Professor, Head of the Department of Ophthalmology

Russian Federation, Saint Petersburg

Natalia V. Lapina

Golikov Research Clinical Center of Toxicology

Email: lapina2005@inbox.ru
SPIN-code: 4385-8991

Cand. Sci. (Med.), Head of the Laboratory of Applied Toxicology and Pharmacology of the Toxicology Department

Russian Federation, Saint Petersburg

Alexander Ya. Bespalov

Golikov Research Clinical Center of Toxicology

Email: bespalov_tox@mail.ru
SPIN-code: 9970-5208

Cand. Sci. (Chem.), Leading Researcher at the Laboratory of Drug Synthesis

Russian Federation, Saint Petersburg

Konstantin A. Krasnov

Golikov Research Clinical Center of Toxicology

Email: krasnov_tox@mail.ru
SPIN-code: 9191-1646

Cand. Sci. (Chem.), Leading Researcher at the Laboratory of Medical Problems of Chemical Safety

Russian Federation, Saint Petersburg

Natalya N. Kharitonova

Kirov Military Medical Academy

Email: natal56@mail.ru
SPIN-code: 9277-7406

Cand. Sci. (Med.), Assistant Professor of Ophthalmology Department

Russian Federation, Saint Petersburg

Roman L. Troyanovskiy

Kirov Military Medical Academy

Email: rltroy@rambler.ru
SPIN-code: 1900-1622

Dr. Sci. (Med.), Professor of the Ophthalmology Department

Russian Federation, Saint Petersburg

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Copyright (c) 2022 Kacherovich P.A., Kulikov A.N., Lapina N.V., Bespalov A.Y., Krasnov K.A., Kharitonova N.N., Troyanovskiy R.L.

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