Intrastromal descemet membrane transplantation in eyes with advanced keratoconus
- Authors: Oganesyan O.G.1,2, Getadaryan V.R.1, Ashikova P.M.1, Makarov P.V.1, Khandzhyan A.T.1
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Affiliations:
- Helmholtz National Medical Research Center of Eye Diseases
- A.I. Evdokimov Moscow State University of Medicine and Dentistry
- Issue: Vol 13, No 2 (2020)
- Pages: 43-48
- Section: Original researches
- URL: https://journals.eco-vector.com/ov/article/view/20425
- DOI: https://doi.org/10.17816/OV20425
- ID: 20425
Cite item
Abstract
Background. To report the outcomes of intrastromal Descemet membrane (DM) transplantation in corneas with advanced keratoconus.
Materials and methods. Three eyes of 3 patients presented with advanced, progressive keratoconus. None of the eyes had prior UV-crosslinking or any other ocular surgery performed. All eyes had a donor DM implanted into a mid-stromal pocket under local anesthesia, and clinical outcomes were evaluated at 12 months after surgery.
Results. To the best of our knowledge, this is the first report of DM transplantation performed in cases of advanced keratoconus. At 12 months after surgery, the DM graft was well positioned and barely visible within the recipient stroma, and all corneas were clear. None of the eyes showed signs of keratoconus progression throughout the follow-up period. No significant changes were observed in uncorrected (UCVA) and best contact lens corrected visual acuity (BCLCVA), central endothelial cell density (ECD), corneal thinnest point (CTP) pachymetry, and maximum keratometry values (SimK and Kmax). No early or late postoperative complications were observed.
Conclusions. Intrastromal DM transplantation may potentially be an alternative to intrastromal Bowman layer transplantation in eyes with advanced keratoconus, to postpone deep anterior lamellar or penetrating keratoplasty.
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About the authors
Oganes G. Oganesyan
Helmholtz National Medical Research Center of Eye Diseases; A.I. Evdokimov Moscow State University of Medicine and Dentistry
Email: oftalmolog@mail.ru
PhD; Department of Ocular Trauma and Reconstructive Surgery
Russian Federation, MoscowVostan R. Getadaryan
Helmholtz National Medical Research Center of Eye Diseases
Author for correspondence.
Email: vostan11@gmail.com
MD
Russian Federation, MoscowPatimat M. Ashikova
Helmholtz National Medical Research Center of Eye Diseases
Email: patiyago@mail.ru
MD
Russian Federation, MoscowPavel V. Makarov
Helmholtz National Medical Research Center of Eye Diseases
Email: makarovpavel61@mail.ru
PhD
Russian Federation, MoscowAnush T. Khandzhyan
Helmholtz National Medical Research Center of Eye Diseases
Email: vostan11@gmail.com
MD, Deputy Director for Commerce
Russian Federation, MoscowReferences
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