The role of genetically determined factors in age-related macular degeneration pathogenesis



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Abstract

The article presents a review of studies dedicated to the role of genetic factors in age-related macular degeneration (AMD) pathogenesis. The polymorphisms of Y402H gene of the complement factor Н, HTRA1, ARMS2/LOC387715, and PLEKHA1 increase the risk of AMD development. More detailed description is done also for other genes, involved into this disease, which were identified so far. Possible schemes of influence of mutations in these genes on AMD development and progression

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About the authors

Svetlana Georgievna Belekhova

First Pavlov State Medical University of St. Petersburg

Email: beleksv@yandex.ru
MD, aspirant. Ophthalmology Department

Yury Sergeevich Astakhov

First Pavlov State Medical University of St. Petersburg

Email: astakhov73@mail.ru
MD, PhD, Doc. Med. Sci., professor. Ophthalmology Department

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