Bilateral lacrimal gland enlargement as a clinical manifestation of sarcoidosis
- 作者: Martirosyan S.S.1,2, Simonyan D.R.1,2, Musheghyan I.K.2, Ghazaryan M.A.2
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隶属关系:
- Ophthalmologic center after S.V. Malayan
- Yerevan State Medical University after Mkhitar Heratsi
- 期: 卷 13, 编号 2 (2020)
- 页面: 89-94
- 栏目: Case reports
- ##submission.dateSubmitted##: 30.03.2020
- ##submission.dateAccepted##: 03.05.2020
- ##submission.datePublished##: 24.08.2020
- URL: https://journals.eco-vector.com/ov/article/view/25854
- DOI: https://doi.org/10.17816/OV25854
- ID: 25854
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Sarcoidosis is an inflammatory disorder of unknown etiology. The main characteristics of sarcoidosis are non-caseating granulomas which can be formed in affected organs. Eye and its adnexal tissues can also be involved. In the early stages of sarcoidosis, the clinical picture may be mild and not always specific. Although the early signs of sarcoidosis are lung associated, we present a clinical case with diffuse enlargement of the lacrimal glands as a first sign of systemic sarcoidosis. A 21-years-old woman presented to the ophthalmological center with a 2-weeks history of having swollen, painful upper eyelids. Primary eye examination revealed palpable tender masses in the locations of the lacrimal glands. Characteristic for sarcoidosis X-ray findings and blood tests demanded lacrimal gland and lung biopsy for diagnosis verification. In spite sarcoidosis of lacrimal glands is a rare condition, it has to be taken into consideration in the differential diagnosis of lacrimal gland masses.
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作者简介
Svetlana Martirosyan
Ophthalmologic center after S.V. Malayan; Yerevan State Medical University after Mkhitar Heratsi
编辑信件的主要联系方式.
Email: martirosyan.svetlana@mail.ru
ORCID iD: 0000-0002-4858-4450
MD, PhD, Ophthalmologist of the External Diseases and Cornea-Uveitis Department; Lecturer of the Ophtalmology Department
亚美尼亚, YerevanDiana Simonyan
Ophthalmologic center after S.V. Malayan; Yerevan State Medical University after Mkhitar Heratsi
Email: dianasimo@mail.ru
ORCID iD: 0000-0002-0743-5053
MD, Ophthalmologist of the External Diseases and Cornea-Uveitis Department; Assistant of the Ophtalmology Department
亚美尼亚, YerevanIlona Musheghyan
Yerevan State Medical University after Mkhitar Heratsi
Email: imushegyan7@mail.ru
ORCID iD: 0000-0002-5879-3715
Student of 5th year, Faculty of General Medicine
亚美尼亚, YerevanMariam Ghazaryan
Yerevan State Medical University after Mkhitar Heratsi
Email: ghmariam98@gmail.com
ORCID iD: 0000-0001-8842-1755
Student of 5th year, Faculty of General Medicine
亚美尼亚, Yerevan参考
- Nunes H, Bouvry D, Soler P, Valeyre D. Sarcoidosis. Orphanet J Rare Dis. 2007;2(1):46. https://doi.org/10.1186/1750-1172-2-46.
- Устинова Е.И. Эндогенные увеиты. Избранные лекции для врачей-офтальмологов. – СПб.: Эко-Вектор, 2017. – С. 95–106. [Ustinova EI. Endogennyye uveity. Izbrannyye lektsii dlya vrachey-oftal’mologov. Saint Petersburg: Eco-Vector; 2017. P. 95-106. (In Russ.)]
- Терпигорев С.А., Эль-Зейн Б.А., Верещагина В.М., Палеев Н.Р. Саркоидоз и проблемы его классификации // Вестник Российской академии медицинских наук. – 2012. – Т. 67. – № 5. – С. 30–37. [Terpigoev SA, El-Zein BA, Vereshchagina VM, Paleev NR. Sarcoidosis: problems in classification. Annals of the Russian Academy of Medical Sciences. 2012;67(5): 30-37. (In Russ.)]. https://doi.org/10.15690/vramn.v67i5.271.
- Prabhakaran VC, Saeed P, Esmaeli B, et al. Orbital and adnexal sarcoidosis. Archives of Ophthalmology. 2007;125(12):1657-1662. https://doi.org/10.1001/archopht.125.12.1657.
- Pasadhika S, Rosenbaum JT. Ocular sarcoidosis. Clinics in Chest Medicine. 2015;36(4):669-683. https://doi.org/10.1016/j.ccm.2015.08.009.
- Ungprasert P, Ryu JH, Matteson EL. Clinical manifestations, diagnosis, and treatment of sarcoidosis. Mayo Clin Proc Innov Qual Outcomes. 2019;3(3):358-375. https://doi.org/10.1016/j.mayocpiqo.2019.04.006.
- Чучалин А.Г., Визель А.А., Илькович М.М., и др. Диагностика и лечение саркоидоза. Резюме федеральных согласительных клинических рекомендаций. Часть I. Классификация, этиопатогенез, клиника // Вестник современной клинической медицины. – 2014. – Т. 7. – № 4. – С. 62–70. [Chuchalin AG, Vizel AA, Ilkovich MM, et al. Diagnosis and treatment of sarcoidosis. Summary of federal conciliative clinical recommendations. Part I. Classification, etiopathogenesis, clinic. Bulletin of contemporary clinical medicine. 2014;7(4):62-70. (In Russ.)]. https://doi.org/10.20969/VSKM.2014.7(4).62-70.
- Mavrikakis I, Rootman J. Diverse clinical presentations of orbital sarcoid. Am J Ophthalmol. 2007;144(5):769-775. https://doi.org/10.1016/j.ajo.2007.07.019.
- Mohan S, Hegde A, Tchoyoson Lim CC. Lacrimal glands: size does matter! Middle East Afr J Ophthalmol. 2011;18(4):328-330. https://doi.org/10.4103/0974-9233.90140.
- Radiopaedia.org. Sharma R, Di Muzio B. Lacrimal gland masses. [cited 2020 Feb 20] Available from: https://radiopaedia.org/articles/lacrimal-gland-masses.
- Rosenbaum JT, Pasadhika S, Crouser ED, et al. Hypothesis: sarcoidosis is a STAT1-mediated disease. Clin Immunol. 2009;132(2):174-183. https://doi.org/10.1016/j.clim.2009. 04.010.
- Baughman RP, Culver DA. Sarcoidosis. Clin Chest Med. 2015;36(4):673. https://doi.org/10.1016/j.ccm.2015.09.001.
- EyeRounds.org. Tsui JY, Allen R. Sarcoidosis affecting the lacrimal gland. [cited 14 Jul 2011]. Available from: http://EyeRounds.org/cases/135-sarcoidosis-lacrimal-gland.htm.
- Sahin O, Ziaei A, Karaismailoğlu E, Taheri N. The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases. BMC Ophthalmol. 2016;16(1):19. https://doi.org/10.1186/s12886-016-0194-4.
- Sharma L, Mihailovic-Vucinic V. Clinical focus series: Lesions of sarcoidosis: A problem solving approach. Jaypee Brothers Medical Publishers; 2014. https://doi.org/10.5005/jp/books/12119_1.
- Matsou A, Tsaousis KT. Management of chronic ocular sarcoidosis: challenges and solutions. Clin Ophthalmol. 2018;12: 519-532. https://doi.org/10.2147/OPTH.S128949.