Bilateral lacrimal gland enlargement as a clinical manifestation of sarcoidosis

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Abstract


Sarcoidosis is an inflammatory disorder of unknown etiology. The main characteristics of sarcoidosis are non-caseating granulomas which can be formed in affected organs. Eye and its adnexal tissues can also be involved. In the early stages of sarcoidosis, the clinical picture may be mild and not always specific. Although the early signs of sarcoidosis are lung associated, we present a clinical case with diffuse enlargement of the lacrimal glands as a first sign of systemic sarcoidosis. A 21-years-old woman presented to the ophthalmological center with a 2-weeks history of having swollen, painful upper eyelids. Primary eye examination revealed palpable tender masses in the locations of the lacrimal glands. Characteristic for sarcoidosis X-ray findings and blood tests demanded lacrimal gland and lung biopsy for diagnosis verification. In spite sarcoidosis of lacrimal glands is a rare condition, it has to be taken into consideration in the differential diagnosis of lacrimal gland masses.


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About the authors

Svetlana S. Martirosyan

Ophthalmologic center after S.V. Malayan; Yerevan State Medical University after Mkhitar Heratsi

Author for correspondence.
Email: martirosyan.svetlana@mail.ru
ORCID iD: 0000-0002-4858-4450

Armenia, Yerevan

MD, PhD, Ophthalmologist of the External Diseases and Cornea-Uveitis Department; Lecturer of the Ophtalmology Department

Diana R. Simonyan

Ophthalmologic center after S.V. Malayan; Yerevan State Medical University after Mkhitar Heratsi

Email: dianasimo@mail.ru
ORCID iD: 0000-0002-0743-5053

Armenia, Yerevan

MD, Ophthalmologist of the External Diseases and Cornea-Uveitis Department; Assistant of the Ophtalmology Department

Ilona K. Musheghyan

Yerevan State Medical University after Mkhitar Heratsi

Email: imushegyan7@mail.ru
ORCID iD: 0000-0002-5879-3715

Armenia, Yerevan

Student of 5th year, Faculty of General Medicine

Mariam A. Ghazaryan

Yerevan State Medical University after Mkhitar Heratsi

Email: ghmariam98@gmail.com
ORCID iD: 0000-0001-8842-1755

Armenia, Yerevan

Student of 5th year, Faculty of General Medicine

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Supplementary files

Supplementary Files Action
1.
Fig. 1. Patient A., 21 yr. Bilateral lacrimal gland enlargement, conjunctival hyperemia: a – right eye; b – left eye

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2.
Fig. 2. Multispiral computed tomography of the orbit. Enlargement of lacrimal glands. Left lacrimal gland is significantly enlarged: a, b – axial projection; c – coronal projection

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3.
Fig. 3. Multispiral computed tomography of the chest. Intrathoracic lymphadenopathy, nodules in the lung parenchyma: a – coronal projection; b, c – axial projection

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4.
Fig. 4. The result of treatment with prednisolone for two weeks: a – right eye; b – left eye

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Copyright (c) 2020 Martirosyan S.S., Simonyan D.R., Musheghyan I.K., Ghazaryan M.A.

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