Physiological Peculiarities of Puberty Period of Adolescents Whose Mothers Were Under High Risk of Terroristic Attack

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INTRODUCTION: The importance of the study is determined by increasing instability of the society and involvement of civilian population in military conflicts.

AIM: To determine peculiarities of sexual development of adolescents whose mothers experienced life-threatening stress in the period preceding pregnancy.

MATERIALS AND METHODS: To evaluate the evidence of the secondary sexual signs, hormonal status, anthropometric data and immunity parameters, 2,980 medical records and data of preventive examinations of schoolchildren of the Republic of Dagestan were analyzed. The observation group included 1,416 schoolchildren whose mothers experienced a life-threatening mental trauma, and the control group included 1,564 adolescents whose mothers did not face life-threatening situations.

RESULTS: The data of a comparative analysis of the regulation of physiological development of sons of women who suffered a life-threatening mental trauma, show multidirectional changes in the concentration of gonadotropic hormones with higher concentrations of estrogens, low levels of androgens, manifested by retardation of the formation of secondary sexual signs, reduced physical strength and endurance in puberty in comparison with boys of the control group. Daughters of mothers who experienced a life-threatening stress, in contrast to girls of the control group, were characterized in puberty by higher levels of luteinizing, follicle-stimulating hormones, earlier development of mammary glands and growth of pubic hair. At the same time, in transition from the prepubertal to pubertal period, these girls were characterized by earlier reduction of the activity of adrenal cortex in these girls, early menarche in the pubertal period and retardation of stabilization of the menstrual cycle rhythm.

CONCLUSION: The adolescents being the offspring of women, who experienced a psychogenic life-threatening trauma, are characterized by disorders in physiologic maturation: boys — by retardation, girls — by acceleration and disharmony of the pubertal development.

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About the authors

Kepiya T. Temirkhanova

Main Bureau of Medical and Social Expertise in the Republic of Dagestan

ORCID iD: 0000-0003-2555-6737
SPIN-code: 7181-5482
ResearcherId: AGS-4519-2022

MD, Cand. Sci. (Med.)

Russian Federation, Makhachkala, Republic of Dagestan

Larisa E. Deryagina

Kikot Moscow University of the Ministry of Internal Affairs of Russia

Author for correspondence.
ORCID iD: 0000-0001-5522-5950
SPIN-code: 6606-6628
ResearcherId: N-5766-2015

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Elena D. Pyatibrat

Military Medical Academy

ORCID iD: 0000-0003-4070-5374
SPIN-code: 9463-7160
Scopus Author ID: 57216180936
ResearcherId: AGS-3602-2022

MD, Dr. Sci. (Med.), Associate Professor

Russian Federation, Saint-Petersburg

Aleksandr O. Pyatibrat

Saint-Petersburg State Pediatric Medical University

ORCID iD: 0000-0001-6285-1132
SPIN-code: 9812-4780
Scopus Author ID: 57203367911
ResearcherId: AGS-3308-2022

MD, Dr. Sci. (Med.), Associate Professor

Russian Federation, Saint-Petersburg


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