Immunohistochemical study of the endocrine cells in the pancreas of the actinopterygian fishes ( Actinopterigii)


The endocrine tissue in the pancreas of 10 actinopterygian fishes (Actinopterigii) species was investigated in present study. Insulin-immunoreactive cells in the most of the studied species (except A. Anguilla, E. Lucius, C. Carpio) had the spherical shape. Glucagon-immunoreactive and somatostatin-immunoreactive cells had the spindle shape with cytoplasmic processes in all species. Insulin-immunoreactive cells were located in the central region of the pancreatic islets; glucagon-immunoreactive cells were located on islet periphery in the most of these species. In A. ruthenus the islets contained only insulin-positive cells. In this case glucagon-and somatostatin-positive cells were distributed around the islets, single cells and small clasters were scaterred throughout the pancreas. In the islets of A. Anguilla, insulin-immunoreactive cells were found in the peripheral region, glucagon-immunoreactive cells were located in the central region. The observed polymorphism of the islets and endocrine cells can not be explained by feeding habits of fishes.

Full Text



  1. Яглов В.В. Морфология эндокринной части поджелудочной железы костистых рыб / В.В. Яглов // Архив анатомии, гистологии и эмбриологии. – 1978. – Т. 74, №1. – С. 111-115.
  2. Bucke D. The anatomy and histology of the alimentary tract of the carnivorous fish the pike Esox lucius L. / D. Bucke // Journal of Fish Biology. – 1971. – Vol. 3, Is. 4 – Р. 421-431.
  3. Epple A.E. Islet histophysiology: Evolutionary correlations / A.E. Epple, J. Brinn // General and Comparative Endocrinology. – 1975. – Vol. 27. – Р. 320-349.
  4. Epple A. The Comparative Physiology of the Pancreatic Islets / A. Epple, J.E. Brinn. – Heidelberg: Springer-Verlag, 1987. – 223 р.
  5. Hampson J. Law relation to animal experimentation / J. Hampson // Laboratory animals: an introduction for new experimenters / ed.: A. A. Tuffery. – Chichester, UK: J.Wiley and Sons Ltd, 1990. – P. 21-52.
  6. Gastroenteropancreatic Hormones (Insulin, Glucagon, Somatostatin, and Multiple Forms of PYY) from the Pallid Sturgeon, Scaphirhynchus albus (Acipenseriformes) / J.В. Kim [et al.] // General and Comparative Endocrinology. – 2000. – Vol. 120, Is. 3. – P. 353-363.
  7. Kobayashi K. Fine structure of Langerhans’ islet cells in a marine teleost Conger japonicus Bleeker / K. Kobayashi, Y. Takahashi // General and Comparative Endocrinology. – 1974. – Vol. 23. – Р. 1-18.
  8. Immunohistochemical study of the endocrine cells in the pancreas of the carp, Cyprinus carpio (Cyprinidae) / H.S. Kong [et al.] // Journal of Veterinary Science. – 2002. – Vol. 3. – Р. 303-314.
  9. Different cellular distributions of two somatostatins in brain and pancreas of salmonids, and their associations with insulin- and glucagon-secreting cells / M. Nozaki [et al.] // General and Comparative Endocrinology. – 1988. – Vol. 69. – Р. 267-280.
  10. Vincent S. The pancreas of teleostean fishes and the source of insulin / S. Vincent, E.C. Dodds, F. Dickens // Experimental Physiology. – 1925. – Vol. 15, N. 3-4. – P. 313-317.
  11. Wagner G.F. Immunocytochemical localization of hormone-producing cells within the pancreatic islets of the rainbow trout (Salmo gairdneri) / G.F. Wagner, B.A. McKeown // Cell Tissue Research. – 1981. – Vol. 221. – Р. 181-192.
  12. Immunocytochemical study of the pancreatic islets of the Pacific salmon, Oncorhynchuys kisutch / Y.-Q. Wang [et al.] // Zoology Science. – 1986. – Vol. 3. – P. 123-129.
  13. The fish endocrine pancreas: Review, new data, and future research directions in ontogeny and phylogeny / J.H. Youson [et al.] // General and Comparative Endocrinology. – 2006. – Vol. 148, Is. 2. – P. 105-115.
  14. Youson J.H. Ontogenetic and Phylogenetic Development of the Endocrine Pancreas (Islet Organ) in Fishes / J.H. Youson, A.A. Al-Mahrouki // General and Comparative Endocrinology. – 1999. – Vol. 116. – Р. 303-335.

Copyright (c) 2012 Savelieva E.S., Proshchina A.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Media Registry Entry of the Federal Service for Supervision of Communications, Information Technology and Mass Communications (Roskomnadzor) PI No. FS77-76803 dated September 24, 2019.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies