THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY

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Abstract


In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.

ВЛИЯНИЕ ЭКСПЕРИМЕНТАЛЬНОЙ ПОДОСТРОЙ ГИПОБАРИЧЕСКОЙ ГИПОКСИЧЕСКОЙ ГИПОКСИИ НА ФУНКЦИОНАЛЬНУЮ АКТИВНОСТЬ ГЛИКОПРОТЕИНА-P

E N Yakusheva

Email: e.yakusheva@rzgmu.ru

I V Chernykh

Email: ivchernykh88@mail.ru

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