Effect of prolongedalcohol consumption ina free elections in the level of sexhormones

Cover Page


In a free choice between 15 -% solution of ethanol and water in a group of 30 male Wistar
rats were distinguished 3 groups on the level of alcohol consumption. Body weight was
increased in groups with middle and high consumption of ethanol. The content of
gonadotropic hormones (LH and FSH) in animals, which consumed the maximum amount of
ethanol, compared with controls was reduced, while urovevn testosterone, both general and
free, were raised in direct proportion to the total amount of consumed ethanol. Index of ratio
of total testosterone increased in proportion to the free consumption of ethanol. Changing
the content in the blood serum of gonadotropic and sex hormones were correlated with the
level of alcohol consumption

About the authors

V A Mkhitarov

Email: mortolhum@mail.ru

V A Mkhitarov


  1. Кушлинский Н.Е., Метаболизм и механизм действия андрогенов / Н.Е. Кушлинский, В.Г. Дегтярь.- М.: Изд-во РАМН, 2005.- 179 с.
  2. Сидоров П.И. Алкогольобусловленные биологические синдромы / П.И. Сидоров, А.Г. Соловьев, И.А. Кирпич // Клинич. наркология.-2005.-№6.- С.31-35.
  3. Шабанов П.Д. Наркология / П.Д. Шабанов.- М.: Гэотар, 2003.- 559 с.
  4. Dyr W. Animal model of ethanol abuse: rats selectively bred for high and low voluntary alcohol intake / W. Dyr, W. Kostowski // Acta Pol Pharm.-2000.- Vol.57.- P.90-92
  5. Dyr W. Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: preliminary phenotypic characterization / W. Dyr, W. Kostowski // Alcohol. -2008- Vol.42,N3.- P.161-170
  6. Gemma S. Individual sesceptibility and alcohol effects: biochemical and genetic aspects / S. Gemma, S. Vichi, E. Testai // Ann Ist Super Sanita.- 2006.- Vol.42.- P.8-16.
  7. Systemic administration of alcohol to adult rats inhibits leydig cell activity: time course of effect and role of nitric oxide / M. Herman [et al.] // Alcoholism: Clin.Exp. Res -. 2006.-Vol. 30,N.9.- P.1479-1491
  8. Nagaraja H.S. Voluntary alcohol drinking & caloric intake in rats exposed to crowding stress / H.S. Nagaraja, P.S. Jeganathan // Indian J Med Res.-2002.- Vol.116.- P.111-116
  9. Ponnappa B.C. Modeling Alcohols effects on organs in animal models / B.C. Ponnappa, E. Rubin // Alcohol Research & Health.- 2000.- Vol. 24,N2.- P. 93- 104.
  10. Neuroactive steroids and ethanol / R.H. Purdy [et al.] // Alcohol Clin Exp Res. -2005.- Vol.29,N7.- P.1292-1298
  11. Chronic daily ethanol and withdrawal: long-term changes in plasma testosterone regulation, but no effect on GnRH gene expression or plasma LH concentrations / D.D. Rasmussen [et al.] // Endocrine.- 2003.- Vol.22, N2.- P.143-150
  12. River C. Alcohol rapidly lowers plasma testosterone levels in the rat: evidence that a neural brain-gonadal pathway may be important for decreased testicular responsiveness to gonadotropin / C. River // Alcoholism: Clin Exp Res.-1999- Vol. 23,N1.- P.38-45
  13. Rok-Bujko P. Operant self-administration of ethanol in Warsaw High-Preferring (WHP) and Warsaw Low-Preferring (WLP) lines of rats / P. Rok-Bujko, W. Dyr, W. Kostowski // Pharmacological Reports.- 2006.- Vol.58.- P.931 - 935.
  14. A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury / G.L. Tipoe [et al.] // Alcohol Clin Exp Res.-2008.- Vol.32,N4.- P.669-682.



Abstract - 305

PDF (Russian) - 199

Article Metrics

Metrics Loading ...



  • There are currently no refbacks.

Copyright (c) 2010 Mkhitarov V.A., Mkhitarov V.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies