Molecular-genetic bases of development of acute pancreatitis
- Authors: Imaeva A.K.1, Nurgaleeva A.K.2, Gallyamova L.F.2, Mustafin T.I.1, Safinova L.S.1, Khusnutdinovna E.K.2,3
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Affiliations:
- Bashkir State Medical University
- Bashkir State University
- Institute of Biochemistry and Genetics of Ufa Federal Scientific Centre of RAS
- Issue: Vol 28, No 4 (2020)
- Pages: 536-547
- Section: Reviews
- URL: https://journals.eco-vector.com/pavlovj/article/view/34156
- DOI: https://doi.org/10.23888/PAVLOVJ2020284536-547
- ID: 34156
Cite item
Abstract
Acute pancreatitis is included into the three most common diseases of organs of the abdominal cavity following acute appendicitis and cholecystitis, with the middle share in this group of 10-16%. As before, acute pancreatitis is characterized by high morbidity and mortality. Many researchers confirm growth of severe forms of the disease with destructive changes in the pancreas.
Aim. A review of literature sources devoted to study of etiology, pathogenesis, classification, diagnosis and molecular-genetic bases of acute pancreatitis. Factors that play a role in development of the disease (episodes of infringement of the diet, cholelithiasis, vascular diseases, abuse of alcohol) are elucidated. Mechanisms of development of acute pancreatitis depending on the etiology, are described in detail, modern classification of acute pancreatitis is given. The main methods of diagnosis of the disease including both laboratory and instrumental ones, are described. Data of the methods of determination of severity of patients’ state based on evaluation of all the most important physiological systems, are presented. In terms of modern understanding of mechanisms of development of acute pancreatitis, the results of investigation of the probability for genetic predisposition to the studied disease are given that opens the ways for optimization of therapy and diagnosis. The results of both individual and large-scale genetic studies of acute pancreatitis are described. Research works with isolation of certain candidate genes whose protein products participate in the pathogenesis of acute pancreatitis, are presented.
Conclusion. A complex approach to diagnosis of acute pancreatitis with identification of different mutations in the studied genes, and also determination of the influence of epigenetic phenomena in the individuals of risk groups will permit to improve the results of the prophylactic, diagnostic and therapeutic activity in acute pancreatitis.
Keywords
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About the authors
Alfiya K. Imaeva
Bashkir State Medical University
Author for correspondence.
Email: Alfia.imaeva@mail.ru
ORCID iD: 0000-0002-3421-0212
SPIN-code: 5205-2002
ResearcherId: AAM-7925-2020
MD, PhD, Associate Professor of the Department of Pathological Anatomy
Russian Federation, 450008, Bashkortostan Republic, Ufa, Lenina street, 3Alfiya K. Nurgaleeva
Bashkir State University
Email: AlfiyaKh83@gmail.com
ORCID iD: 0000-0001-6077-9237
SPIN-code: 9658-8010
ResearcherId: Q-3045-2017
PhD in Biological Sciences, Associate Professor of the Department of Genetics
and Fundamental Medicine
Lilia F. Gallyamova
Bashkir State University
Email: Liliyagallyamova@mail.ru
ORCID iD: 0000-0002-2018-2767
SPIN-code: 1930-1871
ResearcherId: U-1276-2019
Laboratory Assistant of the Molecular Medicine Center
Russian Federation, 450076, Bashkotrostan Respublic, Ufa, Zaki Validi str., 32Tagir I. Mustafin
Bashkir State Medical University
Email: Mustafinti@gmail.com
ORCID iD: 0000-0002-2854-0792
SPIN-code: 7152-4131
MD, PhD, Professor, Head of the Department of Pathological Anatomy
Russian Federation, 450008, Bashkortostan Republic, Ufa, Lenina street, 3Leisen S. Safinova
Bashkir State Medical University
Email: safinovaLSh@mail.ru
ORCID iD: 0000-0003-3388-5987
SPIN-code: 7450-0066
MD, PhD, Associate Professor of the Department of Pathological Anatomy
Russian Federation, 450008, Bashkortostan Republic, Ufa, Lenina street, 3Elza K. Khusnutdinovna
Bashkir State University; Institute of Biochemistry and Genetics of Ufa Federal Scientific Centre of RAS
Email: elzakh@mail.ru
ORCID iD: 0000-0003-2987-3334
SPIN-code: 7408-9797
ResearcherId: A-4810-2013
PhD in Biological Sciences, Professor, AM of REA
Russian Federation, 450054, Ufa, Prospect Oktyabrya str., 71; UfaReferences
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