急性胰腺炎发生的分子遗传学基础

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详细

急性胰腺炎是腹腔最常见的三种疾病之一，其在本组中的平均比例为10-16%。他只承认患有急性阑尾炎和胆囊炎。急性胰腺炎的发病率和死亡率仍然很高。许多研究人员证实，严重的胰腺疾病会随着胰腺的破坏性改变而发展。

目的：对急性胰腺炎的病因、发病机制、分类、诊断及分子遗传学基础的研究文献进行综述。疾病的发展中起作用的因素（饮食失调、胆石症、血管疾病、过量饮酒）被强调。急性胰腺炎的发生机制，取决于疾病的病因，被详细描述，急性胰腺炎的现代分类被描述。保留了一个地方介绍诊断该病的主要方法包括实验室方法和仪器方法。根据对所有重要生理系统的评估，给出了确定患者严重程度的方法的数据。根据现代关于急性胰腺炎发生机制的观点，许多科学家对研究中的疾病的遗传易感性的可能性进行了研究，这为优化治疗和诊断过程开辟了途径。个人和大规模的遗传研究结果在急性胰腺炎的描述。分离某些候选基因的研究，这些候选基因的蛋白产物参与了急性胰腺炎的发病机制。

结果。综合诊断急性胰腺炎的方法，考虑到研究基因中各种突变的鉴定，以及确定高危人群中表观遗传现象的影响，将提高急性胰腺炎预防、治疗和诊断活动的结果。

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作者简介

Alfiya Imaeva

Bashkir State Medical University

编辑信件的主要联系方式.
Email: Alfia.imaeva@mail.ru
ORCID iD: 0000-0002-3421-0212
SPIN 代码: 5205-2002
Researcher ID: AAM-7925-2020

MD, PhD, Associate Professor of the Department of Pathological Anatomy

俄罗斯联邦, 450008, Bashkortostan Republic, Ufa, Lenina street, 3

Alfiya Nurgaleeva

Bashkir State University

Email: AlfiyaKh83@gmail.com
ORCID iD: 0000-0001-6077-9237
SPIN 代码: 9658-8010
Researcher ID: Q-3045-2017

PhD in Biological Sciences, Associate Professor of the Department of Genetics
and Fundamental Medicine

俄罗斯联邦, 450076, Bashkortostan Republic, Ufa, Zaki Validi str., 32

Lilia Gallyamova

Bashkir State University

Email: Liliyagallyamova@mail.ru
ORCID iD: 0000-0002-2018-2767
SPIN 代码: 1930-1871
Researcher ID: U-1276-2019

Laboratory Assistant of the Molecular Medicine Center

俄罗斯联邦, 450076, Bashkotrostan Respublic, Ufa, Zaki Validi str., 32

Tagir Mustafin

Bashkir State Medical University

Email: Mustafinti@gmail.com
ORCID iD: 0000-0002-2854-0792
SPIN 代码: 7152-4131

MD, PhD, Professor, Head of the Department of Pathological Anatomy

俄罗斯联邦, 450008, Bashkortostan Republic, Ufa, Lenina street, 3

Leisen Safinova

Bashkir State Medical University

Email: safinovaLSh@mail.ru
ORCID iD: 0000-0003-3388-5987
SPIN 代码: 7450-0066

MD, PhD, Associate Professor of the Department of Pathological Anatomy

俄罗斯联邦, 450008, Bashkortostan Republic, Ufa, Lenina street, 3

Elza Khusnutdinovna

Bashkir State University; Institute of Biochemistry and Genetics of Ufa Federal Scientific Centre of RAS

Email: elzakh@mail.ru
ORCID iD: 0000-0003-2987-3334
SPIN 代码: 7408-9797
Researcher ID: A-4810-2013

PhD in Biological Sciences, Professor, AM of REA

俄罗斯联邦, 450054, Ufa, Prospect Oktyabrya str., 71; Ufa

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