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THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
- Issue: Vol 21, No 1 (2013)
- Pages: 60-64
- Section: Articles
- URL: https://journals.eco-vector.com/pavlovj/article/view/5129
- DOI: https://doi.org/10.17816/PAVLOVJ2013160-64
- ID: 5129
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Abstract
In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.
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ВЛИЯНИЕ ЭКСПЕРИМЕНТАЛЬНОЙ ПОДОСТРОЙ ГИПОБАРИЧЕСКОЙ ГИПОКСИЧЕСКОЙ ГИПОКСИИ НА ФУНКЦИОНАЛЬНУЮ АКТИВНОСТЬ ГЛИКОПРОТЕИНА-P×
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