Systemic Inflammatory Response Syndrome and Serum Procalcitonin in Odontogenic Maxillofacial Infection

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INTRODUCTION: The systemic inflammatory response syndrome (SIRS) is a progressive, pathophysiological process which may be caused by a variety of clinical precursor events including local or generalized infection, or non-infective inflammatory process.

АIM: To determine the development of systemic inflammatory response syndrome (SIRS) and serum procalcitonin level in patients with odontogenic infection of the maxillofacial area.

MATERIALS AND METHODS: The prospective observational study evaluated on 158 medical patients from 2015 to 2018 at the Department of maxillofacial surgery, Faculty of Stomatology, Vitebsk state medical University. The patients were divided into 3 groups: 1 group (96 people) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of one space cellular spaces, group 2 (36 patients) had acute purulent odontogenic osteomyelitis of mandible complicated by the cellulitis of 2–4 cellular spaces, group 3 (26 people) — had acute purulent odontogenic osteomyelitis of the mandible complicated by Ludwig's angina. Blood tests of all patients were performed. Based on the blood test, breath rate, heart rate and body temperature SIRS was determined.

RESULTS: Acute odontogenic osteomyelitis, complicated by cellulitis, is characterized by the development of SIRS. In case of one cellular space cellulitis SIRS developed in 9.0% of patients, in case of 2–4 cellular spaces cellulitis — in 36.0%, in case of Ludwig's angina — in 80.0%. PCT blood level in healthy group was 0.009 (0.006–0.018) pg/ml. All patients’ groups had significantly higher PCT blood level compared with the healthy group: 1 group — 0.034 (0.019–0.050) pg/ml, U = 23, р = 0.01; 2 group — 0.11 (0.06–0.24) pg/ml, U =12, р = 0.003; 3 group — 0.41 (0.30–1.15) pg/ml, U = 17, р < 0.001.

CONCLUSION: Odontogenic maxillofacial infection is accompanied by SIRS. The search for significant diagnostic criteria for the development of life-threatening conditions should continue.

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作者简介

Arina Kabanova

Vitebsk State Order of Peoples’ Friendship Medical University

编辑信件的主要联系方式.
Email: arinakabanova@mail.ru
ORCID iD: 0000-0002-0121-1139
SPIN 代码: 8930-3890

MD, Dr. Sci. (Med.), Associate Professor

白俄罗斯, Vitebsk

Irina Pokhoden'ko-Chudakova

Belarusian State Medical University

Email: ip-c@yandex.ru
ORCID iD: 0000-0002-0353-0125
SPIN 代码: 9486-9067

MD, Dr. Sci. (Med.), Professor

白俄罗斯, Minsk

Svetlana Kabanova

Vitebsk State Order of Peoples’ Friendship Medical University

Email: chlx.vgmu@mai.ru
ORCID iD: 0000-0001-8165-7570
SPIN 代码: 4916-6722

MD, Cand. Sci. (Med.), Associate Professor

白俄罗斯, Vitebsk

参考

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2. Fig. 1. Presence (%) of SIRS at the patients with odontogenic infection.

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