Parameters of macrophage reaction and humoral immunity in patients with implant-associated in-flammation after primary endoprosthetics of knee joint
- 作者: Galashina E.A.1, Gladkova E.V.1, Blinnikova V.V.1, Shpinyak S.P.1, Ulyanov V.Y.1
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隶属关系:
- Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
- 期: 卷 28, 编号 4 (2020)
- 页面: 421-428
- 栏目: Original study
- ##submission.dateSubmitted##: 21.07.2020
- ##submission.dateAccepted##: 06.11.2020
- ##submission.datePublished##: 15.12.2020
- URL: https://journals.eco-vector.com/pavlovj/article/view/35243
- DOI: https://doi.org/10.23888/PAVLOVJ2020284421-428
- ID: 35243
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Aim. To study peculiarities of macrophage reaction and humoral immunity in patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joint.
Materials and Methods. Examination of 48 patients with signs of implant-associated inflammation after the primary endoprosthetics of the knee joints (the main group) and of 44 patients without signs of inflammatory reactions (comparison group) was carried out. Control group involved 30 healthy donors without diseases of the musculoskeletal system.
Results. In 1 and 12 months after the surgery, patients of the main group showed elevated levels of the factor inhibiting migration of macrophages (MIF), of macrophage stimulating protein (MSP), class A immunoglobulins (IgA), С3 and С4 complement components as compared to control, and also to each previous period. In 1 month after the surgery, the content of class M and G immunoglobulins (IgM and IgG) decreased relative to control; in 12 months after the surgery a more pronounced reduction was noted. Increase in serum concentrations of MIF, MSP, IgA, С3 and С4-complement components was noted in the comparison group in 1 and 12 months and also in comparison with the previous period. Reduction of the levels of IgM, IgG in 1 and 12 months after the operation was noted in comparison with control and with the previous period.
Conclusion. A study of parameters of macrophage reaction, proteins of complement system and the main classes of immunoglobulins permits to identify signs of implant-associated inflammation in 1 and 12 months after surgery, and, consequently, to determine patients of risk groups that require additional diagnostics measures.
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作者简介
Elena Galashina
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
编辑信件的主要联系方式.
Email: koniuchienko1983@mail.ru
ORCID iD: 0000-0001-6209-9120
SPIN 代码: 4016-0672
Scopus 作者 ID: 57190286406
Researcher ID: V-9086-2017
https://www.sarniito.com/
PhD in Biological Sciences, Junior Researcher of the
Department of Fundamental, Clinical and Experimental Researches
Ekaterina Gladkova
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
Email: gladkowa.katya@yandex.ru
ORCID iD: 0000-0002-6207-2275
SPIN 代码: 3837-3244
Scopus 作者 ID: 36722610700
Researcher ID: V-9077-2017
https://www.sarniito.com/
PhD in Biological Sciences, Head of the Department of Fundamental, Clinical and Experimental Researches
俄罗斯联邦, SaratovVeronika Blinnikova
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
Email: bib@sarniito.com
MD, PhD, Doctor of the Clinical Laboratory Diagnostics Department
俄罗斯联邦, SaratovSergey Shpinyak
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
Email: sergos83@rambler.ru
ORCID iD: 0000-0002-0345-6287
SPIN 代码: 6540-1764
Scopus 作者 ID: 57191473935
Researcher ID: A-8021-2018
MD, PhD, Junior Researcher of the Innovative Projects for Traumatology and Orthopedics Department
俄罗斯联邦, SaratovVladimir Ulyanov
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery Razumovsky Saratov State Medical University
Email: v.u.ulyanov@gmail.com
ORCID iD: 0000-0002-9466-8348
SPIN 代码: 8280-3339
Scopus 作者 ID: 56527335300
Researcher ID: A-4073-2014
https://www.sarniito.com/
MD, PhD, Deputy Director for Science and Innovations, Scientific Research Institute of Traumatology
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