Email this article 
Clinical case of an unusual course of coronavirus infection in patient with chronic disseminated pulmonary tuberculosis and human immunodeficiency virus infection
- Authors: Dobin V.L.1, Gorbunov A.V.2, Muratov Y.N.2
-
Affiliations:
- Ryazan State Medical University
- Regional Clinical TB Dispensary
- Issue: Vol 29, No 4 (2021)
- Pages: 539-544
- Section: Clinical reports
- URL: https://journals.eco-vector.com/pavlovj/article/view/65124
- DOI: https://doi.org/10.17816/PAVLOVJ65124
- ID: 65124
Cite item
Open Access
Access granted
Abstract
Introduction: The coronavirus 2019 (COVID-19) pandemic demonstrated a negative influence on many underlying diseases, their course, and prognosis. A combined course of active tuberculosis, human immunodeficiency virus (HIV) infection, and COVID-19 is a rare case in the routine clinical practice; therefore, it is of scientific and practical interest. In a 41-year-old patient with severe chronic disseminated pulmonary tuberculosis and HIV infection, presence of tuberculosis mycobacteria, resistance to streptomycin and isoniazid, chronic respiratory failure, cachexia, and immunodeficiency, COVID-19 was manifested only by the detection of SARS-Cov-2 virus from the nasopharynx and did not influence the treatment and prognosis of tuberculosis.
Conclusion: The described case of a combination of active tuberculosis with HIV infection and COVID-19 demonstrated that effective treatment of specific tuberculosis process is quite possible.
Full Text
About the authors
Vitaly L. Dobin
Ryazan State Medical University
Email: viladob@gmail.com
ORCID iD: 0000-0002-6512-558X
SPIN-code: 7954-9457
ResearcherId: S-8143-2016
Doctor of Medical Sciences, Professor, Head of the Department of Phthisiology with the course of radiation diagnostics
Russian Federation, 9, Vysokovoltnaya, Ryazan 390026Alexei V. Gorbunov
Regional Clinical TB Dispensary
Email: gorbunov.alexei62@mail.ru
ORCID iD: 0000-0003-2915-1024
MD, phthisiatrician of the highest category
Russian Federation, 15, Golenchinskoe shosse, Ryazan 390046Yevgeniy N. Muratov
Regional Clinical TB Dispensary
Author for correspondence.
Email: muratov-1966@list.ru
ORCID iD: 0000-0001-7479-4972
MD, phthisiatrician of the highest category
Russian Federation, 15, Golenchinskoe shosse, Ryazan 390046References
- Huang H, Zhang M, Chen C, et al. Clinical characteristics of COVID-19 in patients with preexisting ILD: A retrospective study in a single center in Wuhan, China. Journal of Medical Virology. 2020;92(11):2742–50. doi: 10.1002/jmv.26174
- Li F, Li W, Farzan M, et al. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005;309(5742):1864–8. doi: 10.1126/science.1116480
- Li X, Zhuang J, Rayford H, et al. Attenuation of bleomycin-induced pulmonary fibrosis by intratracheal administration of antisense oligonucleotides against angiotensinogen mRNA. Current Pharmaceutical Design. 200;13(12):1257–68. doi: 10.2174/138161207780618867
- Uhal BD, Dang M, Dang V, et al. Cell cycle dependence of ACE-2 explains downregulation in idiopathic pulmonary fibrosis. The European Respiratory Journal. 2013;42(1):198–210. doi: 10.1183/09031936.00015612
Supplementary files
