Modeling non-alcoholic fatty liver disease of different severity
- 作者: Brus T.V.1, Vasiliev A.G.1, Vasilieva A.V.1, Pyurveev S.S.1,2, Korablev R.V.1, Bannova A.V.3, Mogileva I.I.1, Daineko M.Y.1, Evgrafov V.A.1, Nudelman N.A.1, Galfanovich I.L.1, Tyumina L.M.1
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隶属关系:
- Saint Petersburg State Pediatric Medical University
- Institute of Experimental Medicine
- V.I. Vernadsky Crimean Federal University
- 期: 卷 16, 编号 1 (2025)
- 页面: 69-78
- 栏目: Original studies
- URL: https://journals.eco-vector.com/pediatr/article/view/681805
- DOI: https://doi.org/10.17816/PED16169-78
- EDN: https://elibrary.ru/TWKNQG
- ID: 681805
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详细
BACKGROUND: One of the priority areas of modern medicine, which unites the interests of various specialists (therapists, cardiologists, gastroenterologists, endocrinologists), is the study of the pathogenesis and clinical manifestations of non-alcoholic fatty liver disease, which is widespread and of unconditional social significance. A search for non-alcoholic fatty liver disease adequate experimental model is of utmost importance for the studies of its etiology and pathogenesis. To understand all pathogenetic peculiarities of this pathology elaboration of hypercaloric hepatopathogenic diet rich in carbohydrates model is of utmost interest.
AIM: The aim of the study was to assess biochemical profile changes including antioxidant system significant markers in rat fructose-induced non-alcoholic fatty liver disease model.
MATERIALS AND METHODS: Two non-alcoholic fatty liver disease model versions were used: a light one — non-alcoholic steatosis and a severe variant — non-alcoholic steatohepatitis.
RESULTS: Both were characteristic of bilirubinemia, cholesterolemia, lipid peroxidation activation and antioxidation mechanisms suppression, cytolitic and cholestatic syndromes.
CONCLUSIONS: The extent of metabolic disorders proved to depend on non-alcoholic fatty liver disease model severity.
全文:

作者简介
Tatiana Brus
Saint Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: bant.90@mail.ru
ORCID iD: 0000-0001-7468-8563
SPIN 代码: 9597-4953
MD, PhD, Associate Professor, Department of Pathological Physiology with a Course of Immunopathology
俄罗斯联邦, Saint PetersburgAndrei Vasiliev
Saint Petersburg State Pediatric Medical University
Email: avas7@mail.ru
ORCID iD: 0000-0002-8539-7128
MD, PhD, Dr. Sci. (Medicine), Professor, Head of the Department of Pathological Physiology with a Course in Immunology
俄罗斯联邦, Saint PetersburgAnna Vasilieva
Saint Petersburg State Pediatric Medical University
Email: anvalvasileva@yandex.ru
SPIN 代码: 5333-0144
Assistant Professor, Department of Pathological Physiology with a Course of Immunopathology
俄罗斯联邦, Saint PetersburgSarng Pyurveev
Saint Petersburg State Pediatric Medical University; Institute of Experimental Medicine
Email: dr.purveev@gmail.com
ORCID iD: 0000-0002-4467-2269
SPIN 代码: 5915-9767
MD, PhD, Assistant Professor, Department of Pathological Physiology with the Course of Immunopathology, Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation; Research Associate, Department of Neuropharmacology, Institute of Experimental Medicine
俄罗斯联邦, Saint Petersburg; Saint PetersburgRodion Korablev
Saint Petersburg State Pediatric Medical University
Email: rodion.korablev@gmail.com
SPIN 代码: 4969-6038
MD, PhD, Associate Professor, Department of Pathological Physiology with a Course of Immunopathology
俄罗斯联邦, Saint PetersburgAnastasiya Bannova
V.I. Vernadsky Crimean Federal University
Email: bannova06@list.ru
ORCID iD: 0009-0007-6867-9477
SPIN 代码: 2034-8324
2nd year student of 1st medical faculty, S.I. Georgievsky Order of the Red Banner of Labor Medical Institute
俄罗斯联邦, SimferopolIrina Mogileva
Saint Petersburg State Pediatric Medical University
Email: flan43@mail.ru
Associate Professor, Head of the Department of Foreign Languages with courses in Russian and Latin
俄罗斯联邦, Saint PetersburgMariya Daineko
Saint Petersburg State Pediatric Medical University
Email: aspirantura@gpmu.org
SPIN 代码: 4188-3230
PhD, Associate Professor, Head of the Department of Foreign Languages with courses in Russian and Latin
俄罗斯联邦, Saint PetersburgVladimir Evgrafov
Saint Petersburg State Pediatric Medical University
Email: psh_k@mail.ru
MD, PhD, Associate Professor, Department of Anesthesiology, Resuscitation and Emergency Pediatrics named after Professor V.I. Gordeev
俄罗斯联邦, Saint PetersburgNatalia Nudelman
Saint Petersburg State Pediatric Medical University
Email: bant.90@mail.ru
SPIN 代码: 5386-8740
Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin
俄罗斯联邦, Saint PetersburgIren Galfanovich
Saint Petersburg State Pediatric Medical University
Email: bant.90@mail.ru
Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin
俄罗斯联邦, Saint PetersburgLyudmila Tyumina
Saint Petersburg State Pediatric Medical University
Email: bant.90@mail.ru
SPIN 代码: 8706-0338
Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin
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