Initial vegetative tone in mild atopic asthma in children

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Abstract

Background. In most industrialized countries, allergic diseases affect up to 20% of the population. This pathology belongs to the most common in children: according to the World Health Organization, more than 15% of the world's child population suffers from it. In recent years, there has been a significant increase in the frequency and more severe course of these diseases, in connection with which they are considered in modern society as a major medical and social problem. Thus, the prevalence of bronchial asthma, according to domestic and foreign authors, ranges from 0.2 to 8.1%.

Purpose. In order to clarify the role of the autonomic nervous system in the genesis of the mild course of atopic bronchial asthma in childhood, the features of the interaction of the sympathetic and parasympathetic divisions of the autonomic nervous system in the examined children were clarified.

Materials and methods. 126 children aged 10 to 14 years were examined. Atopic bronchial asthma was diagnosed in 91 children. At the same time, 61 of them were diagnosed with an intermittent course, 30 – a mild persistent course of the disease. The control group consisted of 35 healthy children also aged 10 to 14 years. Complaints, anamnesis data were studied in all children, an objective and generally accepted laboratory and instrumental examination was carried out. All examined children underwent daily monitoring of the electrocardiogram, according to the results of which, based on the analysis of time and frequency indicators of heart rate variability, a variant of the initial autonomic tone was established.

Results. In children with atopic bronchial asthma, both with intermittent and mild persistent course, an absolute or relative dominance of sympathetic influences was revealed against the background of varying degrees of decrease in parasympathetic activity, which was interpreted as a compensatory reaction of the body in response to chronic allergic inflammation.

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About the authors

Vladimir N. Buryak

I.I. Mechnikov North-West State Medical University of the Ministry of Health of Russia

Author for correspondence.
Email: vladimir.buryak@inbox.ru

MD, PhD, Dr. Sci. (Med.)

Russian Federation, Saint Petersburg

Tatyana I. Antonova

Children's City Polyclinic No. 35 of the Moscow district, Center for Rehabilitation of Children with Allergic Diseases

Email: antian@bk.ru

MD, PhD, Cand. Sci. (Med.), Center for Rehabilitation Treatment of Children with Allergic Diseases

Russian Federation, Saint Petersburg

Maria V. Dudko

Children's City Polyclinic No. 35 of the Moscow district

Email: maria.dudko17@gmail.com

allergist-immunologist, Center for Rehabilitation Treatment of Children with Allergic Diseases

Russian Federation, Saint Petersburg

Inna V. Malysheva

Children's City Polyclinic No. 35 of the Moscow district, Center for Rehabilitation of Children with Allergic Diseases

Email: inness6996@yandex.ru

allergist-immunologist, Center for Rehabilitation of Children with Allergic Diseases

Russian Federation, Saint Petersburg

Kirill K. Shepelenko

Children's City Polyclinic No. 35 of the Moscow district, Center for Rehabilitation of Children with Allergic Diseases

Email: shess08@inbox.ru

allergist-immunologist, Center for Rehabilitation of Children with Allergic Diseases

Russian Federation, Saint Petersburg

References

  1. Балаболкин И.И. Современные подходы к терапии бронхиальной астмы у детей // Педиатрия. Журнал им. Г.Н. Сперанского. – 2016. – Т. 95. – № 4. – С. 131–135. [Balabolkin II. Modern approaches to bronchial asthma treatment in children. Pediatriya – Zhurnal im G.N. Speranskogo. 2016;95(4):131-135. (In Russ.)]
  2. Балаболкин И.И., Булгакова В.А. Бронхиальная астма у детей. – М.: Медицинское информационное агентство, 2015. – 141 с. [Balabolkin II, Bulgakova VA. Bronhial’naja astma u detej. Moscow: Medicinskoe informacionnoe agentstvo, 2015. 141 p. (In Russ.)]
  3. Баранов А.А., Намазова-Баранова Л.С., Хаитов Р.М. Аллергология и иммунология. Аллергический ринит. Клинические рекомендации. – М.: Педиатр, 2020. – 50 с. [Baranov AA, Namazova-Baranova LS, Haitov RM. Allergologija i immunologija. Allergicheskij rinit. Klinicheskie rekomendacii. Moscow: Pediatr, 2020. 50 p. (In Russ.)]
  4. Гостищева Е.В., Тарасова Е.С. Частота встречаемости и причины развития острых аллергических реакций в детском возрасте // Молодой ученый. – 2016. – Т. 2. – № 106. – С. 330–333. [Gostishheva EV, Tarasova ES. Chastota vstrechaemosti i prichiny razvitija ostryh allergicheskih reakcij v detskom vozraste. Molodoj uchenyj. 2016;2(106):330-333. (In Russ.)]
  5. Криволапчук И.А., Герасимова А.А., Чернова М.Б., Мышьяков В.В. Исходный вегетативный тонус в начальный период адаптации к образовательной среде // Новые исследования. – 2017. – Т. 2. – № 51. – С. 12–21. [Krivolapchuk IA, Gerasimova AA, Chernova MB, Mysh’jakov VV. Ishodnyj vegetativnyj tonusv nachal’nyj period adaptacii k obrazovatel’noj srede. Novye issledovanija. 2017;2(51):12-21. (In Russ.)]
  6. Ксензова Л.Д. Атопический марш. Риск развития бронхиальной астмы у детей с атопическим дерматитом // Аллергология и иммунология в педиатрии. – 2018. – Т. 4. – № 55. – С. 25–30. [Ksenzova LD. Atopic march. Risk of developing of allegic rinitis and bronchial asthma in children with atopic dermatitis. Allergology and immunology in pediatrics. 2018;4(55):25-30. (In Russ.)]
  7. Министерство здравоохранения Российской Федерации. Клинические рекомендации. Бронхиальная астма у детей. – 2019. – 76 с. [Ministerstvo zdravoohranenija Rossijskoj Federacii. Klinicheskie rekomendacii. Bronhial’naja astma u detej. 2019. 76 p. (In Russ.)]
  8. Эрназарова Х.Х., Адылова З.У. Распространенность аллергических заболеваний в мире // International scientific review. – 2017. – № 2(33). – С. 111–113. [Ehrnazarova KhKh, Adylova ZU. Rasprostranennost’ allergicheskikh zabolevanii v mire. International scientific review. 2017;(2):111-113. (In Russ.)]
  9. Czarnowicki T, Krueger JG, Guttman-Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march. J Allergy Clin Immunol. 2017;139(6):1723-1734. https://doi.org/10.1016/j.jaci.2017.04.004
  10. Kirkwood BR, Sterne JAC. Essential Medical Statistics, 2nd edition. Blackwell Publishing, 2003. 501 p.

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1. Figure. The state of the initial vegetative tone in the examined patients with atopic form of bronchial asthma of intermittent and mild persistent severity

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Copyright (c) 2021 Buryak V.N., Antonova T.I., Dudko M.V., Malysheva I.V., Shepelenko K.K.

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