Synergic neurotoxic and paraneoplastic neurological syndrome during cysplatin chemotherapy in case of transplanted experimental rat lymphoma

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Abstract

The aim of the study is assessment of combined effect of homotransplanted rat lymphoma (Pliss’ Lymphosrcoma) growth and antitumor therapy (cysplatin) upon the functioning of the nervous system was accomplished in 160 male Wistar rats, divided into four groups: intact animals, rats treated with cysplatin, rats with transplanted lymphoma, and rats with transplanted lymphoma that received cysplatin treatment. The neurologic deficiency degree as well as basic myelin protein peripheral blood level (nervous system impairment hematological marker) were comparatively assessed. Tumor development was accompanied with emergence and subsequent growth of neurologic deficit in locomotory, sensory and coordinative spheres as well as pronounced growth of basic myeline protein plasma level thus making this model a valid test-system for studying paraneoplastic neurologic syndrome. Cysplatin has produced a non-selective toxic effect upon the nervous system of the experimental animals within its therapeutic window range documented by neurotoxic syndrome. Subsequently along with elimination of cysplatin and its derivates from the organism, systemic neurotoxic effect intensity decreased and the nervous system functional state parameters returned to control values. Using cysplatin for the treatment of homotransplanted experimental rat lymphoma results in synergic neurotoxic and paraneoplastic neurological syndrome through combined injury of the nervous system.

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About the authors

Tamara D. Gagloeva

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”; National Research Center “Kurchatov Institute”

Email: gagloeva_td@pnpi.nrcki.ru
SPIN-code: 1056-5503

Junior Research Associate, Center of Preclinical and Clinical Research; Junior Research Associate, Neorocognitive Research Resource Center

Russian Federation, Leningrad Region, Gatchina; Moscow

Alexander P. Trashkov

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”; National Research Center “Kurchatov Institute”

Author for correspondence.
Email: trashkov_ap@pnpi.nrcki.ru
SPIN-code: 4231-1258

MD, PhD, Head, Center of Preclinical and Clinical Research

Russian Federation, Leningrad Region, Gatchina; Moscow

Alexander I. Budko

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”

Email: budko_ai@pnpi.nrcki.ru

MD, PhD, Laboratory Researcher, Center of Preclinical and Clinical Research

Russian Federation, Leningrad Region, Gatchina

Yuliya A. Levkova

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”

Email: levkova_ja@pnpi.nrcki.ru

Laboratory Researcher, Center of Preclinical and Clinical Research

Russian Federation, Leningrad Region, Gatchina

Andrey N. Petrovskiy

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”

Email: petrovskiy_an@pnpi.nrcki.ru

MD, PhD, Senior Research Associate, Center of Preclinical and Clinical Research

Russian Federation, Leningrad Region, Gatchina

Anton B. Cherepov

National Research Center “Kurchatov Institute”

Email: cherepov_ab@nrcki.ru

Leading Engeneer, Resourse Center of Neurocognitive Technologies

Russian Federation, Moscow

Nikolay V. Tsygan

B.P. Konstantinov St. Petersburg Institute of Nuclear Physics of the National Research Center “Kurchatov Institute”; Kirov Military Medical Academy

Email: tsygan_nv@pnpi.nrcki.ru

MD, PhD, Dr. Sci. (Med.), Assistant Professor, Leading Research Associate, Center of Preclinical and Clinical Research; Vice-Head, Department of the Nervous Diseases

Russian Federation, Leningrad Region, Gatchina; Saint Petersburg

Viktor Georgievich Antonov

St. Petersburg State Pediatric Medical University

Email: Mulit7@mail.ru

MD, PhD, Dr. Sci. (Med.), Professor, Professor of the Department of Biological Chemistry

Russian Federation, Saint Petersburg

Mariya A. Pahomova

St. Petersburg State Pediatric Medical University

Email: mariya.pahomova@mail.ru

Senior Research Associate, Research Center

Russian Federation, Saint Petersburg

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2. Figure. Dynamics of tumor growth and its volume in case of treatment with сysplatine in control points of the study

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