The Clinical Case Of Symptomatic Epilepsy In Newborn With Neonatal Hypoglycemic Encephalopathy

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Abstract

Symptomatic epilepsy is common disorder in neonatal period. One of the reasons of symptomatic epilepsy can be neonatal hypoglycemia. Hypoglycemia is the commonest metabolic disorder in neonatal period. Neonatal hypoglycemia can cause neonatal hypoglycemic encephalopathy (NHE) with damage of occipital cortex, symptomatic epilepsy in early postnatal period of life and severe neurological impairment in childhood. Early diagnosis of the NHE is possibly by using brain’s MRI and EEG in neonatal period. Presented clinical case of symptomatic epilepsy in newborn with NHE and results of his clinical examination and findings on brain’s MRI, EEG. There has been performance twice EEG recoding in the acute clinical phase of the hypoglycemic encephalopathy with video monitoring. We used multichannel EEG record in the neonatal modification. Once there has been fulfillment MRI (1,5T scanner) in early period of the case disease (after the convulsion discontinuation). We routinely used T1 weighted imaging, T2 weighted imaging, DWI and Flair. We show the correlation functional brain discharge and structural brain damages by MRI in the case of the neonatal hypoglycemic encephalopathy. The EEG recorded epileptiform activity (sharp theta-waves, spices) in central-occipital and temporal regions. We detected the changes MR-signal from central-occipital and temporal brains regions and thinning of occipital cortex with normal cortex architecture

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About the authors

Tatiana V Melashenko

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: melashenkotat@mail.ru
MD, PhD, Associate Professor Russian Federation

Victoria V Guzeva

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: viktoryka@mail.ru
MD, PhD, Associate Professor, Department of Nervous Diseases Russian Federation

Damir A Malekov

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: d.a.malekov@gmail.com
Assistant Professor, Department of Medical Biophysics Russian Federation

References

  1. Ayfer Akçay, Sanem Yılmaz, Sarenur Gökben, et al. Neurological and developmental outcome of children with neonatal hypoglycemic seizures. İzmir Dr. Behçet Uz Çocuk Hast. Dergisi. 2014;4(1):37-43.
  2. Barkovich AJ, Ali FA, Rowley HA, et al. Imaging patterns of neonatal hypoglycemia. AJNR Am J Neuroradiol. 1998;19:523-28.
  3. Caraballo RH, Sakr D, Mozzi M, et al. Symptomatic occipital lobe epilepsy following neonatal hypoglycemia. Pediatr Neurol. 2004;31:24-29. doi: 10.1016/j.pediatrneurol.2003.12.008.
  4. Choong Yi Fong, A. Simon Harvey. Variable outcome for epilepsy after neonatal hypoglycaemia. Developmental Medicine & Child Neurology. 2014;56(Is11):1093-1099.
  5. Clancy Robert R. Summary Proceedings from the Neurology Group on Neonatal Seizures. Pediatrics. 2006;117:23-27.
  6. Tam EWY, Widjaja E, Blaser SI, et al. Occipital lobe injury and cortical visual outcomes after neonatal gypoglicemia. Pediatrics. 2008;122:507-512. doi: 10.1542/peds.2007-2002.
  7. Tam EWY, Haeusslein LA, Bonifacio SL, et al. Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr. 2012;161(1):88-93. doi: 10.1016/j.jpeds.2011.12.047.
  8. Cowan F. Neonatal Hypoglycemia: Role in Infantile Epilepsy. Indian Pediatrics. 2009;46:122-123.
  9. Glass HC, Hong KJ, Rogers EE, et al. Risk factors for epilepsy in children with neonatal encephalopathy. Ped Res. 2011;70(5):535-540. doi: 10.1203/PDR.0b013e31822f24c7.
  10. Jun Su, Li Wang. Research advances in neonatal hypoglycemic brain injury. Transl Pediatr. 2012;1(2):108-115.
  11. Montassir H, Maegaki Y, Ogura K, et al. Associated factors in neonatal hypoglycemic brain injury. Brain Dev. 2009;3:649-656. doi: 10.1016/j.braindev.2008.10.012.
  12. Montassir H, Maegaki Y, Ohno K, et al. Long term prognosis of symptomatic occipital lobe epilepsy secondary to neonatal hypoglycemia. Epilepsy Res. 2010;88:93-99. doi: 10.1016/j.eplepsyres.2009.10.001.
  13. Sood A, Grover M, Sharma R. Biochemical abnormalities in neonatal seizures. Indian J Pediatr. 2003;70:221-4. doi: 10.1007/BF02725588.
  14. Spar JA, Lewine JD, Orrison WW. Neonatal hypoglycemia: CT and MR findings. AJNR Am J Neuroradiol. 1994;15:1477-78.
  15. Udani V, Munot P, Ursekar M, et al. Neonatal hypoglycemic brain injury: a common cause of infantile onset remote symptomatic epilepsy. Indian Pediatr. 2009;46:127-32.
  16. Wong DST, Poskitt KJ, Chau V, et al. Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy. AJNR Am J Neuroradiol. 2013;34:1456-61. doi: 10.3174/ajnr.A3423.
  17. Yalnizoglu D, Haliloglu G, Turanli G, et al. Neurologic outcome in patients with MRI pattern of damage typical for neonatal hypoglycaemia. Brain Dev. 2007;29:285-292. doi: 10.1016/j.braindev.2006.09.011.

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Copyright (c) 2016 Melashenko T.V., Guzeva V.V., Malekov D.A.

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