电邮这篇文章 Comparison of conducted antiepileptic therapy with indicators of hormones level in blood serum of girls with epilepsy
- 作者: Guzeva V.I1, Guzeva V.V1, Guzeva O.V1
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隶属关系:
- Saint Petersburg State Pediatric Medical University of Health Ministry of Russia
- 期: 卷 7, 编号 1 (2016)
- 页面: 32-42
- 栏目: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/2956
- DOI: https://doi.org/10.17816/PED7132-42
- ID: 2956
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Introduction. Multiple changes in the organism, which are observed in prepubertal and pubertal age, creates the need of clear diagnosis and treatment of the disease based on drugs interactions and their influence on hormonal status. In girls with epilepsy, such studies were not conducted. The aim of the study was to investigate the influence of modern antiepileptic drugs on hormonal status in adolescent girls with epilepsy. Materials and methods. In blood of 50 girls aged 8 to 17 years with epilepsy studied levels of thyroid-stimulating hormone (TSH), thyrogiobulin antibodies (a/b TG), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (P) and cortisol (C). Treatment in most cases included valproic acid, carbamazepine, and topiramate. The main results of the study. In treatment with use of various drugs detected 2 (9.52 %) significant differences in hormone levels and 7 (33.33 %), significant differences in the width of distribution of hormones values. The highest content of thyroid-stimulating hormone found in girls 8-17 years treated by valproic acid, antibodies to thyroglobulin - treatment without AED, triiodothyronine - use of phenobarbital or benzobarbital, thyroxine - treatment on topiramate, PTH - in girls treated by valproic acid, cortisol in girls 8-13 years - on phenobarbital or benzobarbital, girls 14-17 years old - on oxcarbazepine. In 19 girls with epilepsy within 2-12 months after the first study hormone levels of TSH, a/b TG, T3, T4, C were re-determined. Indicators of hormones in different drug treatment changed according to the initial average content of hormones in all girls in 64.86 % of cases same way as in the first study. Conclusions. Significant difference of all hormones, in the content or width of distributions of their values, was found in girls with epilepsy taking different antiepileptic drugs. Choice of drug, dosage and its correction should be made taking into account its impact on children's hormonal status.
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作者简介
Valentina Guzeva
Saint Petersburg State Pediatric Medical University of Health Ministry of Russia
Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University.
Victoria Guzeva
Saint Petersburg State Pediatric Medical University of Health Ministry of Russia
Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Associate Professor, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University
Oksana Guzeva
Saint Petersburg State Pediatric Medical University of Health Ministry of Russia
Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University.
参考
- Гузева В.И. Эпилепсия и неэпилептические пароксизмальные состояния у детей. - М.: Медицинское информационное агентство, 2007. [ Guzeva VI. Epilepsy and non-epileptic paroxysmal conditions in children. Moscow: Medical News Agency; 2007. (In Russ).]
- Гузева В.И., Гузева В.В., Гузева О.В. Анализ показателей уровня гормонов в крови у мальчиков предподросткового и подросткового возраста с эпилепсией при лечении разными противоэпилептическими препаратами // Журнал неврологии и психиатрии имени С.С. Корсакова. - 2008. - № 3. - C. 59-63. [Guzeva VI, Guzeva VV, Guzeva OV. Analysis of hormone levels in blood of preadolescent and adolescent boys with epilepsy treated with various antiepileptic drugs. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2008;(3):59-63. (In Russ).]
- Гузева В.И., Гузева В.В., Гузева О.В. Оценка гормонального профиля у мальчиков препубертатного и пубертатного возраста с эпилепсией // Журнал неврологии и психиатрии имени С.С. Корсакова. - 2008. - № 6. - C. 78-82. [Guzeva VI, Guzeva VV, Guzeva OV. Evaluation of hormonal status in boys of prepubertal and pubertal age with epilepsy. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2008;(6): 78-82. (In Russ).]
- Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. - M.: Медицина, 2010. [Karlov VA. Epilepsy in children and adult women and men. Moscow; 2010. (In Russ).]
- Новикова Н.Е., Гузева В.В., Гузева О.В. Характеристика нейропсихологических особенностей у детей с идиопатическими фокальными формами эпилепсии // Педиатр. - 2011. - Т. 2. - Вып. 3. - C. 52-54. [Novikova NE, Guzeva VV, Guzeva OV. Characteristics of neuropsychological features in children with idiopathic focal forms of epilepsy. Pediatr. 2011;2(3):52-54. (In Russ). ]
- Смирнов Н.В., Дунин-Барковский И.В. Курс теории вероятностей и математической статистики. - М.: Наука, 1969. [Smirnov NV, Dunin-Barkovskiy IV. The course of probability theory and mathematical statistics. Moscow; 1969. (In Russ). ]
- Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30(4): 389-99. doi: 10.1111/j.1528-1157.1989.tb05316.x.
- Herzog AG, Drislane FW, Schomer DL, Pennell PB, Bromfield EB, Dworetzky BA, Farina EL, Frye CA. Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy. Neurology. 2005;65:1016-20.
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