Comparison of conducted antiepileptic therapy with indicators of hormones level in blood serum of girls with epilepsy

Abstract


Introduction. Multiple changes in the organism, which are observed in prepubertal and pubertal age, creates the need of clear diagnosis and treatment of the disease based on drugs interactions and their influence on hormonal status. In girls with epilepsy, such studies were not conducted. The aim of the study was to investigate the influence of modern antiepileptic drugs on hormonal status in adolescent girls with epilepsy. Materials and methods. In blood of 50 girls aged 8 to 17 years with epilepsy studied levels of thyroid-stimulating hormone (TSH), thyrogiobulin antibodies (a/b TG), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (P) and cortisol (C). Treatment in most cases included valproic acid, carbamazepine, and topiramate. The main results of the study. In treatment with use of various drugs detected 2 (9.52 %) significant differences in hormone levels and 7 (33.33 %), significant differences in the width of distribution of hormones values. The highest content of thyroid-stimulating hormone found in girls 8-17 years treated by valproic acid, antibodies to thyroglobulin - treatment without AED, triiodothyronine - use of phenobarbital or benzobarbital, thyroxine - treatment on topiramate, PTH - in girls treated by valproic acid, cortisol in girls 8-13 years - on phenobarbital or benzobarbital, girls 14-17 years old - on oxcarbazepine. In 19 girls with epilepsy within 2-12 months after the first study hormone levels of TSH, a/b TG, T3, T4, C were re-determined. Indicators of hormones in different drug treatment changed according to the initial average content of hormones in all girls in 64.86 % of cases same way as in the first study. Conclusions. Significant difference of all hormones, in the content or width of distributions of their values, was found in girls with epilepsy taking different antiepileptic drugs. Choice of drug, dosage and its correction should be made taking into account its impact on children's hormonal status.

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About the authors

Valentina I Guzeva

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University.

Victoria V Guzeva

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Associate Professor, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University

Oksana V Guzeva

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: viktoryka@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Neurology, Neurosurgery and Medical Genetics. St. Petersburg State Pediatric Medical University.

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