Observation of severe pediatric inflammatory multisystem syndrome associated with COVID-19
- 作者: Efremova O.S.1, Bregel L.V.1, Rudenko N.Y.2, Kniazeva N.A.2, Kostik M.M.3
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隶属关系:
- Irkutsk State Medical Academy of Postgraduate Education, branch of Russian Medical Academy of Continuous Professional Education
- Irkutsk State Regional Children’s Clinical Hospital
- St. Petersburg State Pediatric Medical University
- 期: 卷 14, 编号 1 (2023)
- 页面: 127-134
- 栏目: Clinical observation
- URL: https://journals.eco-vector.com/pediatr/article/view/340774
- DOI: https://doi.org/10.17816/PED141127-134
- ID: 340774
如何引用文章
详细
One of the rare manifestations of COVID-19 is pediatric inflammatory multisystem syndrome, most often in publications it is found out how pediatric inflammatory multisystem syndrome in children (РIMS). The progression of the inflammatory response in РIMS may be a consequence of the development of secondary hemophagocytic syndrome, a significant part of which is refractory fever, an increase in ferritin, AST and ALT, cytopenia, an increase in interleukin 6, severe hepatic and neurological dysfunction. The case with this group of representatives of other multiple organ failure manifestations in the detection of acute distress syndrome and acute heart failure, in the detection of the development of myocarditis.
A feature of the described clinical detection is the dynamic observation of a severe pediatric multisystem inflammatory syndrome associated with COVID-19, complicated by myocarditis with acute heart failure, left ventricular dysfunction and secondary hemophagocytic syndrome, in an 11-year-old girl with underlying obesity. The child is taking triple therapy with glucocorticosteroids in combination with intravenous immunoglobulin and cyclosporine A, with an expected effect on the ongoing treatment. Possible features of observation are noted: 1) a very early start of РIMS during the acute phase of СOVID-19; 2) transient dyslipidemia at the onset of РIMS with an increase in cholesterol, mainly due to the low-density lipoprotein fraction, and spontaneous regression without lipid-lowering drugs; 3) MRI signs of myocarditis in a month after the onset of the disease, despite the normalization of echocardiography and pro-BNP.
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作者简介
Olesya Efremova
Irkutsk State Medical Academy of Postgraduate Education, branch of Russian Medical Academy of Continuous Professional Education
编辑信件的主要联系方式.
Email: shaguno@mail.ru
ORCID iD: 0000-0001-7066-9138
assistant of the Department of pediatrics, cardiologist
俄罗斯联邦, IrkutskLyudmila Bregel
Irkutsk State Medical Academy of Postgraduate Education, branch of Russian Medical Academy of Continuous Professional Education
Email: loudmilabregel@yandex.ru
ORCID iD: 0000-0002-7668-1282
MD, PhD, Dr. Sci. (Med.), professor, head of the Department of pediatrics
俄罗斯联邦, IrkutskNatalia Rudenko
Irkutsk State Regional Children’s Clinical Hospital
Email: nata.rudenko.65@inbox.ru
ORCID iD: 0000-0001-5795-6992
deputy chief medical officer
俄罗斯联邦, IrkutskNatalya Kniazeva
Irkutsk State Regional Children’s Clinical Hospital
Email: nata.rudenko.65@inbox.ru
ORCID iD: 0000-0002-9099-6803
anesthesiologist
俄罗斯联邦, IrkutskMikhail Kostik
St. Petersburg State Pediatric Medical University
Email: kost-mikhail@yandex.ru
ORCID iD: 0000-0002-1180-8086
MD, PhD, Dr. Sci. (Med.), professor of the Department of hospital pediatrics
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