Иннервация костей. Вегетативная иннервация. Часть вторая (обзор литературы)



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Периферические нервы участвуют в развитии, восстановлении и ремоделировании кости..  Симпатическая нервная представляет собой одно из основных связующих звеньев между центральной нервной системой  и скелетом, что подтверждается рядом анатомических, фармакологических и генетических исследований, посвященных передаче сигналов через β-адренорецепторы (βАР) в костных клетках.

Цель — проанализировать публикации, посвященные вкладу автономной нервной системы в контроль метаболизма костной ткани

Материалы и методы. Поиск данных осуществляли в базах научной литературы PubMed, Google Scholar, Cochrane Library, Crossref, eLibrary на английском и русском языках. В процессе написания статьи использовали метод анализа и синтеза информации. Большая часть работ, включенных в данный обзор, опубликована за последние 20 лет.

Результаты: Данные экспериментов in vitro и vivo указывают на то, что адренергические нервные структуры   способствует потере костной массы за счет одновременного усиления катаболизма костей и снижения анаболизма костей.  Активация холинэргических нервных структур подавляет резорбцию костей, что приводит к нарастанию костной массы

Выводы: Влияние вегетативной нервной системы на ремоделирование костной ткани и его основные механизмы в значительной степени изучены в исследованиях на экспериментальных моделях грызунов, однако значимость этих результатов для клинической патофизиологии человека до сих пор остаётся предметом дискуссий, и, независимо от их будущей валидности и практического использования в настоящее время, эти данные представляют собой перспективную базу  для дальнейших исследований

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Алина Михайловна Ходоровская

Национальный медицинский исследовательский центр детской травматологии и ортопедии имени Г.И. Турнера

Автор, ответственный за переписку.
Email: alinamyh@gmail.com
ORCID iD: 0000-0002-2772-6747
SPIN-код: 3348-8038

MD

Россия, Санкт-Петербург

Ольга Евгеньевна Агранович

Национальный медицинский исследовательский центр детской травматологии и ортопедии имени Г.И. Турнера

Email: olga_agranovich@yahoo.com
ORCID iD: 0000-0002-6655-4108
SPIN-код: 4393-3694

д-р мед. наук

Россия, Санкт-Петербург

Маргарита Владимировна Савина

Национальный медицинский исследовательский центр детской травматологии и ортопедии имени Г.И. Турнера

Email: drevma@yandex.ru
ORCID iD: 0000-0001-8225-3885
SPIN-код: 5710-4790
Scopus Author ID: 57193277614

канд. мед. наук

Россия, Санкт-Петербург

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