骨的神经支配。植物性神经支配。第二部分（文献综述）

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外周神经参与骨的发育、修复和重塑。交感神经系统构成中枢神经系统与骨之间的主要纽带之一，这一点已通过多项解剖学、药理学和遗传学研究得到证实，尤其涉及骨细胞中经由β-肾上腺素能受体的信号传递。本文分析了有关自主神经系统在骨组织稳态调控中作用的文献。数据检索于PubMed、 Google Scholar、Cochrane Library、Crossref、eLibrary等数据库，涵盖英文和俄文资料。体外和体内实验数据显示，肾上腺素能神经结构可通过同时增强骨分解和抑制骨形成而导致骨量丢失。胆碱能神经结构的激活则能抑制骨吸收，从而增加骨量。自主神经系统对骨重塑的影响及其主要机制多来自于啮齿类实验动物模型的研究，但这些结果在人类临床病理生理学中的意义至今仍存在争议。然而，无论其未来的有效性和实际应用如何，这些数据仍构成进一步研究的有前景基础。

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作者简介

Alina M. Khodorovskaya

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

编辑信件的主要联系方式.
Email: alinamyh@gmail.com
ORCID iD: 0000-0002-2772-6747
SPIN 代码: 3348-8038

MD

俄罗斯联邦, Saint Petersburg

Olga E. Agranovich

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: olga_agranovich@yahoo.com
ORCID iD: 0000-0002-6655-4108
SPIN 代码: 4393-3694

MD, Dr. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Margarita V. Savina

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: drevma@yandex.ru
ORCID iD: 0000-0001-8225-3885
SPIN 代码: 5710-4790

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Konstantin A. Afonichev

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: afonichev@list.ru
ORCID iD: 0000-0002-6460-2567
SPIN 代码: 5965-6506

MD, Dr. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Yuriy E. Garkavenko

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; North-Western State Medical University named after I.I. Mechnikov

Email: yurijgarkavenko@mail.ru
ORCID iD: 0000-0001-9661-8718
SPIN 代码: 7546-3080

MD, Dr. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg; Saint Petersburg

Evgenii V. Melchenko

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: emelchenko@gmail.com
ORCID iD: 0000-0003-1139-5573
SPIN 代码: 1552-8550

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Anna D. Dreval

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: anndreval@yandex.ru
ORCID iD: 0009-0007-3985-634X
SPIN 代码: 4175-6620
俄罗斯联邦, Saint Petersburg

Daniil B. Vcherashniy

Ioffe Physical Technical Institute

Email: dan-v@yandex.ru
ORCID iD: 0000-0003-1658-789X
SPIN 代码: 6139-7842

Cand. Sci. (Physics and Mathematics)

俄罗斯联邦, Saint Petersburg

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