Email this article 
Evaluation of the clinical efficacy of the use of oxidized dextran in the form of suppositories in the treatment of patients with chronic prostatitis
- Authors: Novikova E.G.1,2, Tikhonov I.V.3, Kasyanov D.S.4, Tityaev I.I.4, Selyatitskaya V.G.1, Troitskii A.V.1
-
Affiliations:
- Federal Research Center of Fundamental and Translational Medicine
- LLC Regional Medical Diagnostic Center
- City Hospital No. 3
- City Clinical Hospital No. 1
- Issue: Vol 13, No 1 (2023)
- Pages: 61-69
- Section: Original articles
- URL: https://journals.eco-vector.com/uroved/article/view/107616
- DOI: https://doi.org/10.17816/uroved107616
- ID: 107616
Cite item
Open Access
Access granted
Abstract
BACKGROUND: Increasing the efficacy of treatment of patients with chronic prostatitis / chronic pelvic pain syndrome remains an urgent problem of modern urology.
AIM: The aim of the study is to evaluate the clinical efficacy of rectal suppositories with oxidized dextran in the treatment of patients with chronic prostatitis / chronic pelvic pain syndrome.
MATERIALS AND METHODS: 52 patients with chronic prostatitis / chronic pelvic pain syndrome were treated (mean age 33.1 ± 1.7 years). The patients were divided into 2 groups. Patients of the 1st group (n = 25) received oxidized dextran in the form of rectal suppositories for 50 days according to the following scheme: for the first 10 days, 1 rectal suppository at night, daily; the next 40 days — 1 rectal suppository every other day. A total of 30 rectal suppositories per course. Patients of the 2nd group (n = 27) received a placebo in the form of rectal suppositories according to the same scheme. Treatment efficacy was assessed on the basis of the original IPPS-MS Genitourinary Disease Assessment questionnaire, the NIH-CPSI and IIEF-5 questionnaires, as well as the results of microscopic examination of prostate secretions.
RESULTS: In patients of the 1st group a significant clinical improvement was revealed by the end of treatment. According to the IPPS-MS questionnaire there was a decrease in the severity of dysuria by 67%, pain syndrome — by 80%, psychosomatic disorders — by 47.6%. There was a decrease in the total score of the NIH-CPSI questionnaire by 66.2% (from 25.4 ± 2.4 to 8.6 ± 2.1 points, p < 0.05) and an increase in the total score of the IIEF-5 questionnaire by 79.3 % (from 11.6 ± 1.8 to 20.8 ± 2.1 points, p < 0.05). Positive changes in the clinical parameters of patients of the 1st group were accompanied by an improvement in the results of microscopy of the secretion of the prostate — a decrease in the number of leukocytes and an increase in the number of lecithin grains. There were no significant changes in any of the studied parameters in patients of the 2nd group. None of the patients in both groups had side effects from the therapy.
CONCLUSIONS: Oxidized dextran in the form of rectal suppositories has a pronounced anti-inflammatory activity and significantly reduces the severity of dysuria, pain and psychosomatic disorders in patients with chronic prostatitis / chronic pelvic pain syndrome. The results of the study indicate the promise of using oxidized dextran in the form of rectal suppositories for the treatment of patients with chronic prostatitis / chronic pelvic pain syndrome.
Full Text
About the authors
Elena G. Novikova
Federal Research Center of Fundamental and Translational Medicine; LLC Regional Medical Diagnostic Center
Email: rmdc.nsk@gmail.com
ORCID iD: 0000-0003-4723-0666
SPIN-code: 8010-3821
MD, Cand. Sci. (Med.), senior research associate of the Laboratory of Endocrinology, urologist-andrologist
Russian Federation, Novosibirsk; NovosibirskIgor V. Tikhonov
City Hospital No. 3
Email: tihonoff2701@yandex.ru
MD, Dr. Sci. (Med.), urologist
Russian Federation, Barnaul, Altay RegionDenis S. Kasyanov
City Clinical Hospital No. 1
Author for correspondence.
Email: kasyanovds@mail.ru
urologist, oncologist
Russian Federation, 6 Zalesskogo st., Novosibirsk 630047Igor I. Tityaev
City Clinical Hospital No. 1
Email: kasyanovds@mail.ru
ORCID iD: 0000-0003-3384-7147
MD, Dr. Sci. (Med.), Professor, urologist of Urology Department
Russian Federation, 6 Zalesskogo st., Novosibirsk 630047Vera G. Selyatitskaya
Federal Research Center of Fundamental and Translational Medicine
Email: vgselyatitskaya@frcftm.ru
ORCID iD: 0000-0003-4534-7289
SPIN-code: 9992-0023
Dr. Sci. (Biol.), Professor, chief research associate, head of the Laboratory of Endocrinology
Russian Federation, NovosibirskAlexander V. Troitskii
Federal Research Center of Fundamental and Translational Medicine
Email: pharm2008@yandex.ru
ORCID iD: 0000-0001-9407-5377
SPIN-code: 6324-0200
Cand. Sci. (Med.), leading research associate, head of the Laboratory of Biocompatible Nanoparticles, Nanomaterials and Targeted Delivery Means
Russian Federation, NovosibirskReferences
- Molochkov VA, Il’in II. Khronicheskii uretrogennyi prostatit. Moscow: Meditsina; 2010. 304 p.
- Paulis G. Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy. Res Rep Urol. 2018;10:75–87. doi: 10.2147/RRU.S170400
- Dendeberov ES, Logvinov LA, Vinogradov IV, Kumachev KV. Taktika vybora skhemy terapii bakterial’nogo prostatita. RMJ. 2011;(32):2071.
- Kulchenko NG, Yatsenko EV. Phytotherapy for inflammatory diseases of the prostate. Research Practical Medicine Journal. 2019;6(3):87–97. (In Russ.) doi: 10.17709/2409-2231-2019-6-3-8
- Vermassen T, Van Praet C, Poelaert F, et al. Diagnostic accuracy of urinary prostate protein glycosylation profiling in prostatitis diagnosis. Biochem Med (Zagreb). 2015;25(3):439–449. doi: 10.11613/BM.2015.045
- Suskind AM, Berry SH, Ewing BA, et al. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study. J Urol. 2013;189(1):141–145. doi: 10.1016/j.juro.2012.08.088
- Pushkar DYu, Rasner PI, Kotenko DV, et al. Specific features of lower urinary tract symptoms in men living in the Moscow Region. Results of the epidemiological study. Urologiia. 2018;(3):20–29. (In Russ.) doi: 10.18565/urology.2018.3.20-28
- Shpilenya ES. Klassifikatsiya UPOINT: osobennosti i preimushchestva. Vestnik Rossiiskogo Obshchestva Urologov. 2019;(2):10. (In Russ.)
- Segal AS. Diagnostika i lechenie khronicheskogo prostatita. RMJ. 2003;(8):453.
- Kogan MI, Ibishev KS, Naboka YL. Etiologicheskaya struktura i antibiotikochuvstvitelnost mikroorganizmov, vydelennykh pri khronicheskom bakterialnom prostatite. Consilium Medicum. 2010;12(7):5–7.
- Tikhonov IV. Kliniko-morfologicheskoe obosnovanie effektivnosti sovmestnogo ispolzovaniya nizkointensivnogo lazernogo izlucheniya i KVCh-terapii pri lechenii distsirkulyatornogo prostatita In: Materials of the IX International Scientific and Practical Conference “Nauchnoe partnerstvo”. Belgrad: Nauka i studia; 2013. Vol. 24. P. 3–5. (In Russ.)
- Tikhonov IV, Kazakov OV. Regionarnye limfaticheskie uzly prostaty pri eksperimental’nom distsirkulyatornom prostatite i v usloviyakh ego korrektsii KVCh- i nizkointensivnym lazernym izlucheniem. In: Materials of the IX International Scientific and Practical Conference “Nauchnoe partnerstvo” Sofia: Byal GRAD-BG,; 2013. Vol. 30. P. 77–83. (In Russ.)
- Tikhonov IV, Tityaev II, Kas’yanov DS, et al. Sistemnyi podkhod v kompleksnom lechenii kongestivnogo prostatita s sindromom khronicheskoi tazovoi boli. Metodicheskie rekomendatsii dlya vrachei urologov, andrologov, kurortologov. Novosibirsk; 2021. 32 p.
- Kliniko-morfologicheskoe obosnovanie ispolzovaniya rektalnykh svechei «Endogem» pri khronicheskom prostatite. In: Materials of the I Interdisciplinary Congress “Produktsiya na osnove syr’ya pantovogo olenevodstva. Aktualnye problemy i perspektivy ee ispolzovaniya v meditsine i sporte vysshikh dostizhenii”, Barnaul; 2015. P. 39–42.
- Novikova EG, Troitsky AV, Ukah HU, Selyatitskaya VG. Experimental study on the efficiency of rectal suppositories with oxidized dextran in patients with benign prostatic hyperplasia. Urologiia. 2021;(5):59–61. (In Russ.) doi: 10.18565/urology.2021.5.59-61
- Potapova OV, Sharkova TV, Cherdantseva LA, et al. Preventive effects of oxidized dextran on functional activity of pulmonary macrophages in mice infected with influenza A virus. Bulletin of Experimental Biology and Medicine. 2018;165(1):57–60. (In Russ.)
- Tkachev VO, Kolesnikova OP, Troitsky AV, Shkurupij VA. Effect of oxidized dextran on NO-synthase and arginase activity of mouse macrophages. Bulletin of Experimental Biology and Medicine. 2008;146(7):91–93. (In Russ.)
- Potapova OV, Shkurupij VA, Sharkova TV, et al. Preventive efficacy of oxidized dextran and pathomorphological processes in mouse lungs in avian influenza a/h5n1. Bulletin of Experimental Biology and Medicine. 2010;150(12):650–653. (In Russ.)
- Guan X, Zhao C, Ou ZY, et al. Use of the UPOINT phenotype system in treating Chinese patients with chronic prostatitis/chronic pelvic pain syndrome: a prospective study. Asian J Androl. 2015;17(1):120–123. doi: 10.4103/1008-682X.138189
- Tihonov IV, Tityaev II, Kasyanov DS, Chekushin RH. Application of pantohematogen dry for treatment of discirculatory disorders in chronic prostatitis (experimental and clinical study). Urology Reports (St. Petersburg). 2021;11(1):63–68. (In Russ.) doi: 10.17816/uroved50229
Supplementary files
There are no supplementary files to display.
